Evidence map›Paper›PMID 42353015›Full record

ArticleInternational journal of molecular sciences2026

Assessment of Factors Regulating Androgen Receptor (AR) and Estrogen Receptor Alpha (ERα) Expression in Men with End-Stage Hip Osteoarthritis.

Aleksandra Rył, Marta Grabowska, Alina Jurewicz, Andrzej Bohatyrewicz, Aleksandra Szylińska, Weronika Ratajczak, Małgorzata Piasecka, Katarzyna Michałek, Anna Lubkowska, Iwona Rotter

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aleksandra RyłDepartment of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University in Szczecin, 54 Żołnierska, 71-210 Szczecin, Poland.ORCID 0000-0002-5954-4489
Marta GrabowskaDepartment of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, 48 Żołnierska, 71-210 Szczecin, Poland.ORCID 0000-0003-0861-0738
Alina JurewiczDepartment of Specialized Nursing, Pomeranian Medical University in Szczecin, 48 Żołnierska Street, 71-210 Szczecin, Poland.ORCID 0000-0002-2822-858X
Andrzej BohatyrewiczDepartment of Orthopedics, Traumatology and Musculoskeletal Oncology, Pomeranian Medical University in Szczecin, 1 Unii Lubelskiej, 71-252 Szczecin, Poland.
Aleksandra SzylińskaDepartment of Cardiac Surgery, Pomeranian Medical University in Szczecin, 72 Powstańców Wielkopolskich, 70-111 Szczecin, Poland.ORCID 0000-0001-6105-5329
Weronika RatajczakDepartment and Division of Functional Diagnostics and Physical Medicine, Pomeranian Medical University in Szczecin, 54 Żołnierska, 71-210 Szczecin, Poland.
Małgorzata PiaseckaDepartment of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, 48 Żołnierska, 71-210 Szczecin, Poland.ORCID 0000-0002-5914-2121
Katarzyna MichałekDepartment of Physiology, Cytobiology and Proteomics, Faculty of Biotechnology and Animal Sciences, West Pomeranian University of Technology in Szczecin, 29 Klemensa Janickiego, 71-270 Szczecin, Poland.ORCID 0000-0001-7201-328X
Anna LubkowskaDepartment and Division of Functional Diagnostics and Physical Medicine, Pomeranian Medical University in Szczecin, 54 Żołnierska, 71-210 Szczecin, Poland.ORCID 0000-0002-5378-5409
Iwona RotterDepartment of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University in Szczecin, 54 Żołnierska, 71-210 Szczecin, Poland.

Funding

National Science Centre 2018/02/X/NZ4/00128
6 · The paper itself

Abstract

This study aimed to identify environmental and hormonal determinants of steroid receptor expression in the bone tissue of men with osteoarthritis. Twenty-six men undergoing total hip arthroplasty were included. Serum hormones, bone turnover markers, and elemental concentrations were assessed, and bone samples were analyzed using immunohistochemistry and multivariate regression models. Results: Estrogen receptor alpha (ERα) expression was a significant positive predictor of the bone formation marker procollagen type I N-terminal propeptide (PINP) (

Indexed as

Estrogen Receptor alphaOsteoarthritis, HipReceptors, AndrogenAgedBiomarkersHumansMaleMiddle AgedPeptide FragmentsProcollagenAR protein, humanBiomarkersESR1 protein, humanEstrogen Receptor alphaPeptide FragmentsProcollagenprocollagen Type I N-terminal peptideReceptors, Androgenandrogen receptor (AR)bone tissueestrogen receptor alpha (ERα)osteoarthritis (OA)

Identifiers

PMID42353015
PMCPMC13299116

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.