Evidence map›Paper›PMID 42353036›Full record

ArticleInternational journal of molecular sciences2026

Gingivitis Pathogenesis Involves Upregulation of Glycolysis and Citric Acid Cycle Activity Mediated by Bacterial Virulence Factors.

Sancai Xie, Malgorzata Klukowska, Jiazhen Wang, Tom Huggins, Julie Ashe, Cheryl S Tansky, Lijuan Li, Benjamin Circello, Niranjan Ramji, Donald J White and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sancai XieCorporate Functions R&D, The Procter & Gamble Company, Mason, OH 45040, USA.ORCID 0009-0004-8266-0455
Malgorzata KlukowskaGlobal Oral Care R&D, The Procter & Gamble Company, Mason, OH 45040, USA.
Jiazhen WangCorporate Functions R&D, The Procter & Gamble Company, Mason, OH 45040, USA.
Tom HugginsCorporate Functions R&D, The Procter & Gamble Company, Mason, OH 45040, USA.ORCID 0000-0001-5311-8860
Julie AsheCorporate Functions R&D, The Procter & Gamble Company, Mason, OH 45040, USA.
Cheryl S TanskyGlobal Baby, Feminine, Family Care Life Sciences, The Procter & Gamble Company, Cincinnati, OH 45224, USA.
Lijuan LiCorporate Functions R&D, The Procter & Gamble Company, Mason, OH 45040, USA.ORCID 0000-0002-9512-5441
Benjamin CircelloCorporate Functions R&D, The Procter & Gamble Company, Mason, OH 45040, USA.
Niranjan RamjiGlobal Oral Care R&D, The Procter & Gamble Company, Mason, OH 45040, USA.
Donald J WhiteGlobal Oral Care R&D, The Procter & Gamble Company, Mason, OH 45040, USA.
Aaron R BiesbrockGlobal Oral Care R&D, The Procter & Gamble Company, Mason, OH 45040, USA.

Funding

Procter & Gamble (United States) N/A
6 · The paper itself

Abstract

This research analyzed metabolomic and proteomic differences between participants with gingivitis (>20 bleeding sites) and generally healthy participants (≤3 bleeding sites) at baseline and 4 weeks post stannous fluoride (SnF

Indexed as

Citric Acid CycleGingivitisGlycolysisVirulence FactorsAdultCytokinesFemaleHumansMaleProteomicsTin FluoridesTriose-Phosphate IsomeraseUp-RegulationCytokinesTin FluoridesTriose-Phosphate IsomeraseVirulence Factorsadenosine triphosphategingivitislipopolysaccharidemalate dehydrogenaseoral lavageouter membrane vesiclesstannous fluoridetriosephosphate isomerase

Identifiers

PMID42353036
PMCPMC13299710

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.