Evidence map›Paper›PMID 42353172›Full record

ArticleInternational journal of molecular sciences2026

Lactate-Mediated Brain Acidosis Drives Epigenetic Dysregulation of TGFB2 and Associated Gene Networks in Schizophrenia and Bipolar Disorder.

Hamid Mostafavi Abdolmaleky, Shabnam Nohesara, Reshma Subramonian, Kodhai Duraiarasan, Melissa Dorzin, Jin-Rong Zhou, Giuseppe Pettinato, Sam Thiagalingam

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hamid Mostafavi AbdolmalekyDepartment of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0002-8872-5174
Shabnam NohesaraDepartment of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.ORCID 0000-0003-4944-7033
Reshma SubramonianDepartment of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.
Kodhai DuraiarasanDepartment of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.
Melissa DorzinDepartment of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0009-0008-1093-6896
Jin-Rong ZhouDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Giuseppe PettinatoDepartment of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0001-6785-6370
Sam ThiagalingamDepartment of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.ORCID 0000-0001-5211-266X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene expression analyses of postmortem brains have identified hundreds of dysregulated genes in schizophrenia (SCZ) and bipolar disorder (BD). Lactate accumulation and reduced brain pH are also consistently reported in these disorders. As increased TGFB expression has been implicated in major psychiatric diseases and lactic acid induces

Indexed as

AcidosisBipolar DisorderBrainEpigenesis, GeneticGene Regulatory NetworksLactic AcidSchizophreniaTransforming Growth Factor beta2AstrocytesDNA MethylationHumansHydrogen-Ion ConcentrationInduced Pluripotent Stem CellsMaleNeuronsPromoter Regions, GeneticLactic AcidTGFB2 protein, humanTransforming Growth Factor beta2astrocytebipolar disorderbrain organoidbrain pHDNA hydroxymethylationDNA methylationiPSClactic acidschizophreniaTGFB2

Identifiers

PMID42353172
PMCPMC13299459

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.