Evidence mapPaperPMID 42353208Full record

ArticleInternational journal of molecular sciences2026

Metformin Enhances 2-Aminoethyl Dihydrogen Phosphate-Induced Mitochondrial Dysfunction and Apoptosis in Melanoma Cells.

Thalles Anthony Duarte de Oliveira, Gustavo Henrique Doná Rodrigues Almeida, Sergio Mestieri Chammas, Rosa Andrea Nogueira Laiso, Yasmim Emilly Moreira Sousa, Ícaro Gabriel Teles Pacheco de Matos, Valherya Silva Rodriguez, Beatriz Cristine Bittencourt Queiroz, Ariane Clemente Alves Oliveira, Sara de Lima and 5 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Thalles Anthony Duarte de OliveiraGraduate Program in Anatomy of Domestic and Wild Animals, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo 05508-270, Brazil.
Gustavo Henrique Doná Rodrigues AlmeidaDevelopment and Innovation Laboratory, Butantan Institute, São Paulo 05503-900, Brazil.ORCID 0000-0003-2640-8250
Sergio Mestieri ChammasDevelopment and Innovation Laboratory, Butantan Institute, São Paulo 05503-900, Brazil.
Rosa Andrea Nogueira LaisoGraduate Program in Anatomy of Domestic and Wild Animals, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo 05508-270, Brazil.
Yasmim Emilly Moreira SousaDevelopment and Innovation Laboratory, Butantan Institute, São Paulo 05503-900, Brazil.
Ícaro Gabriel Teles Pacheco de MatosDevelopment and Innovation Laboratory, Butantan Institute, São Paulo 05503-900, Brazil.
Valherya Silva RodriguezDevelopment and Innovation Laboratory, Butantan Institute, São Paulo 05503-900, Brazil.
Beatriz Cristine Bittencourt QueirozDevelopment and Innovation Laboratory, Butantan Institute, São Paulo 05503-900, Brazil.ORCID 0009-0008-3968-9833
Ariane Clemente Alves OliveiraDevelopment and Innovation Laboratory, Butantan Institute, São Paulo 05503-900, Brazil.
Sara de LimaDevelopment and Innovation Laboratory, Butantan Institute, São Paulo 05503-900, Brazil.
Laís Araujo Martins de ArrudaDevelopment and Innovation Laboratory, Butantan Institute, São Paulo 05503-900, Brazil.
Daniel da Conceição RabeloGraduate Program in Anatomy of Domestic and Wild Animals, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo 05508-270, Brazil.
Rose Eli Grassi RiciGraduate Program in Anatomy of Domestic and Wild Animals, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo 05508-270, Brazil.
Paulo Cézar de Freitas MathiasGraduate Program in Biological Sciences, State University of Maringá, Maringá 87020-900, Brazil.
Durvanei Augusto MariaGraduate Program in Anatomy of Domestic and Wild Animals, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo 05508-270, Brazil.

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/11946-9National Council for Scientific and Technological Development 305056/2019-0
6 · The paper itself

Abstract

Melanoma exhibits pronounced metabolic plasticity and mitochondrial dependency, contributing to therapeutic resistance and tumor progression. Targeting mitochondrial function therefore represents a promising anticancer strategy. 2-Aminoethyl dihydrogen phosphate (2-AEH

Indexed as

ApoptosisMelanomaMetforminMitochondriaAnimalsAntineoplastic AgentsCell Line, TumorCell ProliferationCell SurvivalHumansMembrane Potential, MitochondrialMiceAntineoplastic AgentsMetformin2-AEH2Pmelanomametformintumor metabolism

Identifiers

PMID42353208
PMCPMC13299214

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.