Evidence mapPaperPMID 42353262Full record

ArticleInternational journal of molecular sciences2026

A Bone-Protective Role for IFN-γ? Evidence from Genetic Association and Osteoblast Functional Assays in Postmenopausal Osteoporosis.

Camilla Albertina Dantas de Lima, Anna Paula Oliveira Souza, Maria Aparecida Barreto Lopes Seabra, Werbson Lima Guaraná, Bianca Maria Ribeiro de Oliveira, Sergio Crovella, Alexandre Domingues Barbosa, Jaqueline de Azevêdo Silva, Paula Sandrin-Garcia

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Camilla Albertina Dantas de LimaDepartment of Oceanography, Federal University of Pernambuco (UFPE), Recife 50670-901, PE, Brazil.ORCID 0000-0003-0320-3674
Anna Paula Oliveira SouzaBiomedical Engineering Laboratory, Federal University of Pernambuco (UFPE), Recife 50670-901, PE, Brazil.
Maria Aparecida Barreto Lopes SeabraDepartment of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL 32611, USA.
Werbson Lima GuaranáLaboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Recife 50670-901, PE, Brazil.ORCID 0000-0003-1806-5219
Bianca Maria Ribeiro de OliveiraLaboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Recife 50670-901, PE, Brazil.ORCID 0009-0001-2612-519X
Sergio CrovellaLaboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Recife 50670-901, PE, Brazil.ORCID 0000-0001-8493-1168
Alexandre Domingues BarbosaRheumatology Division, Clinical Hospital of Federal University of Pernambuco, Recife 50670-901, PE, Brazil.
Jaqueline de Azevêdo SilvaLaboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Recife 50670-901, PE, Brazil.ORCID 0000-0003-1660-7299
Paula Sandrin-GarciaLaboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Recife 50670-901, PE, Brazil.ORCID 0000-0003-4641-7429

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoporosis (OP) is a complex disease in which several immune-related genes have been identified as contributing to susceptibility and disease progression. Despite efforts to achieve functional validation, many of these genes, such as interferon-gamma (

Indexed as

Interferon-gammaOsteoblastsOsteoporosis, PostmenopausalAgedAllelesCase-Control StudiesFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansMiddle AgedPolymorphism, Single NucleotideInterferon-gammabone environmentprotein expressionrs2069705SNV

Identifiers

PMID42353262
PMCPMC13299862

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.