Evidence mapPaperPMID 42353267Full record

ReviewInternational journal of molecular sciences2026

Neuroprotection in Early Diabetic Retinal Disease Using Eyedrop Delivery.

Hugo Ramos, Olga Simó-Servat, Cristina Hernández, Rafael Simó

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hugo RamosDiabetes and Metabolism Research Unit, Vall d'Hebron Research Institute (VHIR), 08035 Barcelona, Spain.ORCID 0000-0001-6443-7576
Olga Simó-ServatDiabetes and Metabolism Research Unit, Vall d'Hebron Research Institute (VHIR), 08035 Barcelona, Spain.ORCID 0000-0003-3483-652X
Cristina HernándezDiabetes and Metabolism Research Unit, Vall d'Hebron Research Institute (VHIR), 08035 Barcelona, Spain.ORCID 0000-0002-3109-1721
Rafael SimóDiabetes and Metabolism Research Unit, Vall d'Hebron Research Institute (VHIR), 08035 Barcelona, Spain.ORCID 0000-0003-0475-3096

Funding

Institute of Health Carlos III ICI20-/00129Ministry of Economy and Competitiveness PID2019-104225RB-100; SAF2016-77784; SAF 2012-35562Ministry of Science and Information PID2022-138544OB-I00; PDC2021-121638-I00Universidad Técnica Estatal de Quevedo PTQ2023-013246
6 · The paper itself

Abstract

Diabetic retinal disease (DRD) has classically been defined as a microvascular complication of diabetes; however, the recent evidence highlighted the key role of neuronal degeneration during the earliest stages of its pathogenesis. Therefore, neuroprotection has emerged as a promising therapeutic strategy to prevent disease progression. Topical administration via eyedrops represents a non-invasive approach to deliver neuroprotective agents directly to the retina. This review summarizes the current advances in the field of neuroprotective therapies against early DRD with a special focus on topical delivery, including preclinical and clinical evidence, while discussing the relevance of the transscleral route of absorption in all of them. In this review, the most promising neuroprotective compounds under development will be discussed, highlighting the opportunity that they represent for treating early stages of DRD.

Indexed as

Diabetic RetinopathyNeuroprotectionNeuroprotective AgentsOphthalmic SolutionsAnimalsHumansRetinaNeuroprotective AgentsOphthalmic Solutionsdiabetic retinal diseasediabetic retinopathyeyedropsglaucomaneurodegenerationneuroprotectionretinatransscleral

Identifiers

PMID42353267
PMCPMC13299816

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.