Evidence map›Paper›PMID 42353595›Full record

ReviewCurrent issues in molecular biology2026

One Diet Does Not Fit All: A Systematic Review and Meta-Analysis of Gene-Diet Interactions Affecting Blood Lipid Profiles.

Saba Iordanishvili, Nazibrola Chiradze, Dodo Agladze, Marine Kikvidze, Revaz Solomonia, Vincenzo Lagani

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Saba IordanishviliInstitute of Chemical Biology, School of Natural Sciences and Medicine, Ilia State University, Tbilisi 0179, Georgia.
Nazibrola ChiradzeDiabetes, Endocrine, and Metabolism Department, LTD Diacor-The Center for Diabetes, Endocrine and Cardiopulmonary Diseases, Tbilisi 0159, Georgia.
Dodo AgladzeDepartment of Clinical Genetics, Medical Genetics and Laboratory Diagnostic Center, Tbilisi 0159, Georgia.ORCID 0009-0001-4353-653X
Marine KikvidzeInstitute of Chemical Biology, School of Natural Sciences and Medicine, Ilia State University, Tbilisi 0179, Georgia.ORCID 0009-0005-8594-3861
Revaz SolomoniaInstitute of Chemical Biology, School of Natural Sciences and Medicine, Ilia State University, Tbilisi 0179, Georgia.
Vincenzo LaganiInstitute of Chemical Biology, School of Natural Sciences and Medicine, Ilia State University, Tbilisi 0179, Georgia.ORCID 0000-0002-6552-6076

Funding

Shota Rustaveli National Science Foundation PHDF-22-3124
6 · The paper itself

Abstract

Blood lipid responses to diet vary substantially between individuals, limiting the effectiveness of uniform dietary recommendations, and genetic variation may contribute to this heterogeneity through gene-diet interactions. This systematic review and meta-analysis evaluated nutrigenetic interactions affecting blood lipid traits. Web of Science Core Collection and MEDLINE were searched in April 2026 to identify human studies testing interactions between dietary exposures-including macronutrient composition, fat quantity, fat type [polyunsaturated fatty acids (PUFA), monounsaturated fatty acids (MUFA), and saturated fatty acids (SFA)], carbohydrate, and protein-and lipid-related genes. Interaction

Indexed as

APOEblood lipidsCETPdietary fatgene–diet interactionslipid metabolismmeta-analysispolyunsaturated fatty acidsprecision nutritionsystematic review

Identifiers

PMID42353595
PMCPMC13297643

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.