Evidence map›Paper›PMID 42353628›Full record

ArticleCurrent issues in molecular biology2026

Modulatory Activity of Uncaria tomentosa Extract in the Expression of Proteins Involved in the Unfolded Protein Response and Insulin Resistance.

Bruna Freitas Marchi, Vittoria de Lima Camandona, Athirson Moraes Chanavat, Gustavo Roncoli Reigado, Carla Roberta de Oliveira Carvalho, Felipe Santiago Chambergo, Viviane Abreu Nunes

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In one paragraph

Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bruna Freitas MarchiDepartment of Chemistry and Molecular Biology, University of Gothenburg (GU), 413 90 Göteborg, Sweden.
Vittoria de Lima CamandonaLaboratory of Aging and Molecular Biology, School of Arts, Sciences and Humanities, University of Sao Paulo (EACH-USP), São Paulo 03828-000, Brazil.
Athirson Moraes ChanavatLaboratory of Skin Physiology and Tissue Bioengineering, School of Arts, Sciences and Humanities, University of Sao Paulo (EACH-USP), São Paulo 03828-000, Brazil.
Gustavo Roncoli ReigadoLaboratory of Skin Physiology and Tissue Bioengineering, School of Arts, Sciences and Humanities, University of Sao Paulo (EACH-USP), São Paulo 03828-000, Brazil.
Carla Roberta de Oliveira CarvalhoDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo (ICB-USP), São Paulo 05508-000, Brazil.ORCID 0000-0001-5824-8656
Felipe Santiago ChambergoLaboratory of Skin Physiology and Tissue Bioengineering, School of Arts, Sciences and Humanities, University of Sao Paulo (EACH-USP), São Paulo 03828-000, Brazil.ORCID 0000-0001-7567-0656
Viviane Abreu NunesLaboratory of Skin Physiology and Tissue Bioengineering, School of Arts, Sciences and Humanities, University of Sao Paulo (EACH-USP), São Paulo 03828-000, Brazil.ORCID 0000-0003-0861-4392

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2016/14150-2Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/11693-0
6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2D) is associated with dyslipidemia, characterized by elevated plasmatic triglycerides and free fatty acids, particularly palmitate (PA), which may cause lipotoxicity in skeletal muscle cells. This leads to inflammation, activation of the unfolded protein response (UPR), insulin resistance, and cell death. Herbal medicines such as

Indexed as

insulin resistancepalmitatetype 2 diabetes mellitusUncaria tomentosaunfolded protein response

Identifiers

PMID42353628
PMCPMC13298498

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.