ArticleAntibiotics (Basel, Switzerland)2026
Targeting Membrane Transport and Energy Metabolism for the Identification of Repurposed Drug Candidates Against
Inês Pereira, André Pina, Inês Vítor, Beatriz Santos, Ana Henriques, Isabel Couto, Filomena M Pereira, Miguel Viveiros, Ana Armada, Sofia Santos Costa and 1 more
Abstract read
In one paragraphArticle in Antibiotics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Inês PereiraGlobal Health and Tropical Medicine, GHTM, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, 1349-008 Lisboa, Portugal.ORCID 0009-0006-2206-4138 André PinaGlobal Health and Tropical Medicine, GHTM, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, 1349-008 Lisboa, Portugal.
Inês VítorGlobal Health and Tropical Medicine, GHTM, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, 1349-008 Lisboa, Portugal.ORCID 0009-0009-5003-1001 Beatriz SantosGlobal Health and Tropical Medicine, GHTM, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, 1349-008 Lisboa, Portugal.
Ana HenriquesGlobal Health and Tropical Medicine, GHTM, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, 1349-008 Lisboa, Portugal.
Isabel CoutoGlobal Health and Tropical Medicine, GHTM, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, 1349-008 Lisboa, Portugal.ORCID 0000-0003-3536-2733 Filomena M PereiraGlobal Health and Tropical Medicine, GHTM, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, 1349-008 Lisboa, Portugal.ORCID 0000-0003-3421-7833 Miguel ViveirosGlobal Health and Tropical Medicine, GHTM, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, 1349-008 Lisboa, Portugal.ORCID 0000-0001-9676-6251 Ana ArmadaGlobal Health and Tropical Medicine, GHTM, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, 1349-008 Lisboa, Portugal.ORCID 0000-0001-5066-9982 Sofia Santos CostaGlobal Health and Tropical Medicine, GHTM, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, 1349-008 Lisboa, Portugal.ORCID 0000-0002-4096-2410 Liliana RodriguesGlobal Health and Tropical Medicine, GHTM, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, 1349-008 Lisboa, Portugal.
Funding
Fundação para a Ciência e Tecnologia LA/P/0117/2020Fundação para a Ciência e Tecnologia UID/04413/2025Global Health and Tropical Medicine UID/04413/2020-DrugsForNg
6 · The paper itselfAbstract
BACKGROUND/
objectives
methodsPredicted drug-target interactions were identified using publicly available databases such as DrugBank and STITCH. Minimum inhibitory concentrations (MICs) of selected drugs against
resultsIn silico analysis identified 32 predicted targets associated with 57 approved drugs. Triclabendazole and dequalinium showed the lowest MIC values of the tested compounds (2 and 4 mg/L, respectively). Ketotifen and verapamil demonstrated activity consistent with possible efflux interference, as indicated by increased ethidium bromide accumulation. Atovaquone showed adjuvant-like effects in combination assays, suggesting that mechanisms other than efflux-related interference may contribute to its activity.
conclusionsOverall, this preliminary study identifies approved drugs with antimicrobial or adjuvant activity against a single
Indexed as
antimicrobial resistancedrug repurposingefflux pumpsenergy metabolismin silico drug repurposingNeisseria gonorrhoeae
Identifiers
PMID42353739
PMCPMC13295694
What Socratic holds
Textmetadata
LicenceCC BY
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