ArticleGenes2026
Functional Characterization of Fad Genes from Two Chemosymbiotic Bivalves Inhabiting the Haima Cold Seep.
Article in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
BACKGROUND/
objectivesChemosymbiotic bivalves play a fundamental role in deep-sea cold seep and hydrothermal vent ecosystems, where essential long-chain polyunsaturated fatty acids (LC-PUFAs) are scarce. Whether these bivalves retain the capacity for endogenous PUFA synthesis remains poorly understood. Here, we investigated the PUFA biosynthetic capacity of two dominant chemosymbiotic bivalves from the Haima cold seep-the mussel
methodsGenome and transcriptome assembly revealed three fatty acid desaturase (
resultsBoth Fads3 enzymes (Δ6/8 clade) convert C20:3n-6 and C20:4n-3 into C20:4n-6 and C20:5n-3, respectively, exhibiting Δ8-desaturase activity. Notably, Δ5-clade isoforms showed divergent substrate specificities:
conclusionsTogether, our results reveal that cold-seep bivalves retain endogenous LC-PUFA biosynthetic capacity and have evolved duplicated Δ5-desaturases with novel regioselectivity toward bacterial MUFAs, likely representing an adaptive membrane modification for survival under extreme deep-sea conditions.
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