ArticleChildren (Basel, Switzerland)2026
Associations of Serum Zinc and Iron with Systemic Inflammatory Indices in Pediatric Obesity: An Exploratory Cross-Sectional Study.
Article in Children (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesChildhood obesity is associated with chronic low-grade systemic inflammation. This exploratory cross-sectional study aimed to evaluate associations between a comprehensive panel of serum micronutrient levels and four systemic inflammatory indices-neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and monocyte-to-lymphocyte ratio (MLR)-in a pediatric cohort, with iron as the primary focus and zinc as a secondary exploratory analysis.
methodsWe included 410 children (mean age 7.2 ± 3.8 years; 205 male) attending a tertiary pediatric clinic. Of these, 399 had complete BMI percentile data and were included in obesity-stratified analyses; patients were classified as having obesity (BMI ≥ 95th percentile;
resultsAll four inflammatory indices were significantly higher in children with obesity (SII: 487.1 vs. 332.1,
conclusionsSystemic inflammatory burden is elevated in children with obesity. Iron shows consistent associations with inflammatory indices independent of age and BMI. Zinc shows a potentially relevant, exploratory association with inflammation, specifically in the subgroup with obesity, warranting replication in adequately powered prospective studies. These findings are consistent with a role for iron status assessment in the clinical evaluation of pediatric obesity and warrant further prospective investigation of zinc-related inflammatory associations.
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