ReviewMicromachines2026
Single-Molecule Detection Concepts Enabled by DNA Origami.
Review in Micromachines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Since its introduction in 2006, DNA origami has enabled the fabrication of a wide variety of two- and three-dimensional DNA nanostructures. From the very beginning, researchers have explored these nanostructures as programmable nanobreadboards with hundreds of uniquely addressable positions, allowing precise spatial arrangement of biomolecules, fluorophores, and nanoparticles. This capability has been leveraged to create functional DNA nanomachines capable of single-molecule detection. Here, DNA origami is utilized to precisely engineer various nanoarchitectures, such as conformational switches and plasmonic hotspots. Through coupling of these concepts with tailored readout strategies, true single-molecule detection can be achieved. This literature review systematically examines the development of DNA origami-based single-molecule detection concepts. We first explore general design principles to produce functional DNA nanostructures, followed by an overview of non-fluorescence-based approaches employing atomic force microscopy, nanopores, and optical nanoantennas with surface-enhanced Raman spectroscopy readout, as well as fluorescence-based approaches relying on dynamic DNA nanostructures and optical nanoantennas with fluorescent readout. We highlight key trends as well as the remaining technology gaps that should be bridged to further advance DNA origami towards next-generation single-molecule detection.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.