Evidence mapPaperPMID 42354951Full record

ReviewMicroorganisms2026

The Gut-Vagina Axis.

Lorenzo Agoni, Elena Roselletti, Giovanni Marasco, Canio Martinelli, Eva Pericolini, Francesco De Seta

Abstract readReview
In one paragraph

Review in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lorenzo AgoniUnit of Obstetrics and Gynecology, Fondazione Poliambulanza Istituto Ospedaliero, 25124 Brescia, Italy.
Elena RosellettiDepartment of Biosciences, Faculty of Health and Life Sciences, Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter EX4 4QD, UK.ORCID 0000-0003-3929-7502
Giovanni MarascoDepartment of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0001-7167-8773
Canio MartinelliSbarro Institute for Cancer Research and Molecular Medicine and Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.ORCID 0000-0002-0587-8467
Eva PericoliniDepartment of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, 41124 Modena, Italy.ORCID 0000-0002-5299-8197
Francesco De SetaDepartment of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.ORCID 0000-0003-1611-0813

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut-vagina axis has emerged as a growing area of interest in female health due to its potential role in mediating physiological processes via interactions between distinct microbiomes, including microbial migration, hormonal and immune regulation, and metabolite exchange. Recent advances in microbiome research suggest bidirectional communication between gut and vaginal communities, with potential effects on microbial composition, immune responses, hormonal balance, and metabolic activity in both sites. In this review, we outline the most promising features of the gut-vaginal relationship, emphasize the significance of their plausible bidirectional communication, and discuss how these interactions may affect local and systemic health.

Indexed as

gut microbiomegut–vagina axismicrobiomevaginal microbiome

Identifiers

PMID42354951
PMCPMC13305437

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.