ReviewLife (Basel, Switzerland)2026
Human Sperm Centrosome: From Current Evidence to Future Perspectives-A Systematic Review.
Review in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe sperm centrosome is a key organelle composed of two centrioles surrounded by pericentriolar material and is essential for sperm aster formation and first mitotic spindle formation after sperm entry into the oocyte, thereby supporting early embryonic development.
methodsThis systematic review evaluated 83 publications published between 1986 and 2026 to provide an updated overview of the human sperm centrosome, including its structural organization, protein composition, role in reproductive success, and association with embryonic abnormalities.
resultsThe available evidence indicates that centrosome-associated proteins such as centrin, γ-tubulin, and pericentrin are critical for spindle assembly, microtubule nucleation, and centriole duplication, and that alterations in their expression or localization are associated with poor sperm quality and reduced fertilization potential. Centrosomal dysfunction has also been linked to fertilization failure despite intracytoplasmic sperm injection, abnormal embryo cleavage, and possible embryonic aneuploidy. Although diagnostic approaches have improved, targeted treatments remain limited.
conclusionsThese findings highlight the clinical relevance of sperm centrosomal integrity and support the need for further research into its diagnostic and therapeutic implications.
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