Evidence map›Paper›PMID 42356231›Full record

Trial reportNutrients2026

Effect of Inulin-Type Fructans on Body Composition, Carbohydrate Metabolism and Energy Expenditure in Patients with Psoriasis: Results of INGUTSKIN Randomized Controlled Trial.

Karolina Bieglecka, Paulina Katarzyna Kęszycka, Joanna Czerwińska, Krzysztof Pastuszak, Ewa Lange, Agnieszka Owczarczyk-Saczonek, Urszula Krupa-Kozak

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05971992 (Effect of Intestinal Microbiota Modulation Induced by the Chicory Inulin-type β-fructans on Metabolic Parameters and Biomarkers of the Gut-skin Axis in Chronic Skin Inflammation), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05971992 nacompletednot on this map

Effect of Intestinal Microbiota Modulation Induced by the Chicory Inulin-type β-fructans on Metabolic Parameters and Biomarkers of the Gut-skin Axis in Chronic Skin Inflammation

TypeinterventionalSponsorPolish Academy of SciencesRan2023 to 2024Enrolled56ConditionsPsoriasisArmsChicory-derived inulin-type β-fructans, Maltodextrin
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Karolina BiegleckaChemistry and Biodynamics of Food Team, InLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10-683 Olsztyn, Poland.ORCID 0009-0008-6353-7987
Paulina Katarzyna KęszyckaDepartment of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences-SGGW, 02-787 Warsaw, Poland.ORCID 0000-0003-1302-9171
Joanna CzerwińskaDepartment of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, The University of Warmia and Mazury, 10-229 Olsztyn, Poland.ORCID 0000-0001-6371-8130
Krzysztof PastuszakDepartment of Algorithms and System Modelling, Gdańsk University of Technology, 80-233 Gdańsk, Poland.ORCID 0000-0002-5562-0114
Ewa LangeDepartment of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences-SGGW, 02-787 Warsaw, Poland.ORCID 0000-0003-1093-4571
Agnieszka Owczarczyk-SaczonekDepartment of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, The University of Warmia and Mazury, 10-229 Olsztyn, Poland.ORCID 0000-0002-8372-0438
Urszula Krupa-KozakChemistry and Biodynamics of Food Team, InLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10-683 Olsztyn, Poland.ORCID 0000-0001-8580-2851

Funding

National Science Centre 2022/45/B/NZ9/03004
6 · The paper itself

Abstract

introductionPatients with psoriasis, a non-contagious, chronic, systemic inflammatory skin disease, often suffer from carbohydrate metabolism disorders, which can exacerbate systemic inflammation.

methodsThis randomized, double-blind, placebo-controlled trial (RCT) evaluated the effects of chicory-derived inulin-type fructans (ITFs) on body composition, energy expenditure, and carbohydrate metabolism in patients with mild psoriasis (PS), using a healthy control (

resultsAt baseline, patients with PS had significantly (

conclusionsPatients with PS exhibit a higher metabolic risk than healthy controls. Although no significant changes were observed within the intervention groups, the deterioration of metabolic indices in the placebo group may indicate an unfavorable effect of the maltodextrin. Consequently, the stabilization of parameters in the prebiotic group should be interpreted with great caution. This RCT was registered at ClinicalTrials.gov (NCT05971992).

Indexed as

Body CompositionCarbohydrate MetabolismEnergy MetabolismFructansInulinPsoriasisAdultBlood GlucoseBody Mass IndexDouble-Blind MethodFemaleHumansInsulinMaleMiddle AgedPrebioticsBlood GlucoseFructansInsulinInulinPrebioticsanthropometric indicesbioelectrical impedance analysisBMIchronic skin inflammationprebioticresting energy expenditure

Identifiers

PMID42356231
PMCPMC13305044

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.