Evidence map›Paper›PMID 42356314›Full record

ArticleNutrients2026

Natto May Alleviate Retinoic Acid-Induced Osteoporosis by Activating Gut Microbiota-Bile Acid Axis and OPG/RANKL Signaling Pathway.

Bimi Zhang, Mubai Sun, Yongfu Liu, Tong Pan, Xuecong Zhang, Yuguang He, Xuetong Gan, Da Li, Xinyu Miao, Zhengyang Luo and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bimi ZhangInstitute of Agro-Food Technology, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, China.
Mubai SunInstitute of Agro-Food Technology, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, China.
Yongfu LiuJilin Province Agricultural Product Processing Promotion Center, Changchun 130022, China.
Tong PanInstitute of Agro-Food Technology, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, China.ORCID 0009-0009-7880-8337
Xuecong ZhangInstitute of Agro-Food Technology, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, China.
Yuguang HeInstitute of Agro-Food Technology, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, China.
Xuetong GanInstitute of Agro-Food Technology, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, China.
Da LiInstitute of Agro-Food Technology, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, China.
Xinyu MiaoInstitute of Agro-Food Technology, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, China.
Zhengyang LuoInstitute of Agro-Food Technology, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, China.
Honghong NiuInstitute of Agro-Food Technology, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, China.
Mei HuaInstitute of Agro-Food Technology, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, China.ORCID 0000-0002-7524-8065
Jinghui WangInstitute of Agro-Food Technology, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, China.ORCID 0009-0002-3125-2107

Funding

Jilin Province agricultural science and technology basic scientific research business fee KYJF2023JJ103Jilin Province Agricultural Science and Technology Innovation Project CXGC2025ZD012; CXGC2023RCY026
6 · The paper itself

Abstract

backgroundNatto, a well-known fermented soybean product beneficial for bone health, remains unclear in its mechanism.

methodsThis study investigated its effect on secondary osteoporosis (OP) in mice.

resultsNatto significantly inhibited weight loss, bone quality deterioration, and bone morphological damage, and regulated OPG/RANKL pathway protein expression (

conclusionsIn summary, natto may act on gut microbiota to alleviate bone loss via the "gut microbiota-bile acid-OPG/RANKL" network, targeting multiple organs including gut, liver, and bone. This provides a theoretical basis for natto dietary intervention in osteoporosis prevention through the gut-bone axis.

Indexed as

Bile Acids and SaltsFermented FoodsGastrointestinal MicrobiomeOsteoporosisOsteoprotegerinRANK LigandTretinoinAnimalsMaleMiceMice, Inbred C57BLSignal TransductionBile Acids and SaltsOsteoprotegerinRANK LigandTnfrsf11b protein, mouseTnfsf11 protein, mouseTretinoinbile acid synthesisgut microbiotanattoOPG/RANKL signaling pathwayosteoporosisserum metabolome

Identifiers

PMID42356314
PMCPMC13304610

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.