Evidence mapPaperPMID 42357439Full record

ArticleMolecules (Basel, Switzerland)2026

Adsorption Behavior of Chiral Pharmaceuticals onto Montmorillonite Clay: Evaluating Removal Efficiency and Stereoselectivity.

Gül Gülenay Hacıosmanoğlu, Marina Arenas, Carmen Mejías, Julia Martín, Juan Luis Santos, Irene Aparicio, Esteban Alonso

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gül Gülenay HacıosmanoğluEnvironmental Engineering Department, Faculty of Engineering, Marmara University, Uyanık Cd. No. 6, 34840 Istanbul, Turkey.ORCID 0000-0003-1674-0305
Marina ArenasDepartamento de Química Analítica, Escuela Politécnica Superior, Universidad de Sevilla, C/Virgen de África 7, E-41011 Sevilla, Spain.ORCID 0000-0003-1530-5985
Carmen MejíasDepartamento de Química Analítica, Escuela Politécnica Superior, Universidad de Sevilla, C/Virgen de África 7, E-41011 Sevilla, Spain.ORCID 0000-0001-7966-830X
Julia MartínDepartamento de Química Analítica, Escuela Politécnica Superior, Universidad de Sevilla, C/Virgen de África 7, E-41011 Sevilla, Spain.ORCID 0000-0003-3621-1291
Juan Luis SantosDepartamento de Química Analítica, Escuela Politécnica Superior, Universidad de Sevilla, C/Virgen de África 7, E-41011 Sevilla, Spain.ORCID 0000-0001-9704-1316
Irene AparicioDepartamento de Química Analítica, Escuela Politécnica Superior, Universidad de Sevilla, C/Virgen de África 7, E-41011 Sevilla, Spain.ORCID 0000-0002-5468-9021
Esteban AlonsoDepartamento de Química Analítica, Escuela Politécnica Superior, Universidad de Sevilla, C/Virgen de África 7, E-41011 Sevilla, Spain.ORCID 0000-0002-1647-9226

Funding

Ministry of Science, Innovation PID2023-148571OB-I00
6 · The paper itself

Abstract

Chiral pharmaceuticals (CPs) have gained growing attention in environmental studies regarding the differential behavior of individual enantiomers in racemic mixtures. This study investigates the stereoselectivity and efficiency of montmorillonite (MMT), a natural and low-cost adsorbent, for the removal of a wide group chiral pharmaceuticals and metabolites (atenolol, propranolol, metoprolol, fluoxetine, venlafaxine, norfluoxetine, and O-desmethylvenlafaxine). The effects of adsorption conditions including initial CP concentration, contact time, adsorbent dose, solution pH, and humic acid content were evaluated. In most adsorption experiments, no significant stereoselective behavior was observed, except for the case where a low adsorbent dose was applied. Interestingly, as the solution humic acid content increased (up to 40 mg/L), the adsorption capacity was increased for most of the target CPs. Isotherm studies revealed that the Freundlich model described the experimental data well and the process was favorable. Adsorption mechanism was interpreted by material characterization before and after adsorption. High removal efficiencies (88.0 to 99.8%) and the non-enantioselective behavior of MMT indicate that it can be used effectively for the simultaneous removal of both enantiomeric forms of various chiral pharmaceuticals from aqueous matrices.

Indexed as

BentoniteClayWater Pollutants, ChemicalAdsorptionHumic SubstancesHydrogen-Ion ConcentrationKineticsPharmaceutical PreparationsStereoisomerismWater PurificationBentoniteClayHumic SubstancesPharmaceutical PreparationsWater Pollutants, Chemicaladsorptionchiral pharmaceuticalsenantiomersmontmorillonitewastewaterwater

Identifiers

PMID42357439
PMCPMC13304480

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.