Evidence map›Paper›PMID 42357508›Full record

ArticleMolecules (Basel, Switzerland)2026

Diosmetin Modulates EMT-Associated Plasticity and Fibroblast-Activation Markers in Parallel Breast Cancer In Vitro Models.

Monika Michalczyk, Joanna Kubik, Aleksandra Józefczyk, Magdalena Iwan, Ewelina Humeniuk, Grzegorz Adamczuk, Mariola Michalczuk, Barbara Madej-Czerwonka, Maciej Czerwonka, Agnieszka Korga-Plewko

Abstract read
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In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Monika MichalczykDoctoral School, Medical University of Lublin, 7 Chodzki Street, 20-093 Lublin, Poland.
Joanna KubikIndependent Medical Biology Unit, Faculty of Pharmacy, Medical University of Lublin, 8b Jaczewskiego Street, 20-090 Lublin, Poland.ORCID 0000-0002-2766-3870
Aleksandra JózefczykDepartment of Pharmacognosy with Medicinal Plants Garden, Faculty of Pharmacy, Medical University of Lublin, 1 Chodzki Street, 20-093 Lublin, Poland.ORCID 0000-0001-6033-4692
Magdalena IwanDepartment of Toxicology, Faculty of Pharmacy, Medical University of Lublin, 6 Chodzki Street, 20-093 Lublin, Poland.ORCID 0000-0002-7834-0828
Ewelina HumeniukIndependent Medical Biology Unit, Faculty of Pharmacy, Medical University of Lublin, 8b Jaczewskiego Street, 20-090 Lublin, Poland.ORCID 0000-0003-4356-0828
Grzegorz AdamczukDepartment of Physiology and Toxicology, Institute of Medical Science, Faculty of Medicine, John Paul II Catholic University of Lublin, 1H Konstantynow, 20-708 Lublin, Poland.ORCID 0000-0003-1677-7247
Mariola MichalczukIndependent Medical Biology Unit, Faculty of Pharmacy, Medical University of Lublin, 8b Jaczewskiego Street, 20-090 Lublin, Poland.
Barbara Madej-CzerwonkaHuman Anatomy Department, Faculty of Medicine, Medical University of Lublin, 4 Jaczewskiego Street, 20-090 Lublin, Poland.ORCID 0000-0002-2165-9651
Maciej CzerwonkaDepartment of General, Oncological, Gastroenterological and Transplant Surgery, University Hospital in Krakow, Jagiellonian University, 2 Jakubowski Street, 30-688 Krakow, Poland.ORCID 0000-0001-8007-5982
Agnieszka Korga-PlewkoIndependent Medical Biology Unit, Faculty of Pharmacy, Medical University of Lublin, 8b Jaczewskiego Street, 20-090 Lublin, Poland.ORCID 0000-0002-2027-9681

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metastasis remains the leading cause of mortality in breast cancer and is closely linked to epithelial-mesenchymal transition (EMT) and tumor microenvironment (TME)-associated processes. Diosmetin (DT), the active metabolite of diosmin, a widely used venoactive drug, has emerged as a potential anticancer agent. Building on our previous findings demonstrating that DT enhances doxorubicin efficacy, this study investigated its effects on tumor cell plasticity and stromal activation-associated responses. EMT was induced in MCF-7 cells, while a stromal model was established by TGF-β-mediated activation of BJ fibroblasts toward a cancer-associated fibroblast (CAF)-like phenotype. Additionally, doxorubicin-induced senescence was generated in fibroblasts. Migration assays and quantitative real-time PCR were used to assess functional and transcriptional changes. EMT induction resulted in decreased

Indexed as

Breast NeoplasmsCancer-Associated FibroblastsCell PlasticityEpithelial-Mesenchymal TransitionFibroblastsFlavonoidsCell Line, TumorCell MovementCellular SenescenceDoxorubicinFemaleGene Expression Regulation, NeoplasticHumansMCF-7 CellsTransforming Growth Factor betaTumor MicroenvironmentdiosmetinDoxorubicinFlavonoidsTransforming Growth Factor betaanticancer activitiesbreast cancercancer-associated fibroblastsdiosmetinepithelial–mesenchymal transitionnatural productsenescence

Identifiers

PMID42357508
PMCPMC13304686

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.