DESI-MSI-Based Multi-Organ Distribution Mapping of Psilocin in Zebrafish.

Mengxuan Dong, Yi Zhang, Manzhu Cao, Tong Shi, Liqin Li, Xingxing Zong, Chen Wang

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mengxuan DongState Key Laboratory of Chemistry for NBC Hazards Protection, Beijing 102205, China.

Yi ZhangState Key Laboratory of Chemistry for NBC Hazards Protection, Beijing 102205, China.

Manzhu CaoState Key Laboratory of Chemistry for NBC Hazards Protection, Beijing 102205, China.

Tong ShiState Key Laboratory of Chemistry for NBC Hazards Protection, Beijing 102205, China.

Liqin LiState Key Laboratory of Chemistry for NBC Hazards Protection, Beijing 102205, China.

Xingxing ZongState Key Laboratory of Chemistry for NBC Hazards Protection, Beijing 102205, China.ORCID 0000-0002-5214-3180

Chen WangState Key Laboratory of Chemistry for NBC Hazards Protection, Beijing 102205, China.ORCID 0000-0002-7553-0941

Funding

State Key Laboratory of Chemistry for NBC Protection SKLNBC2024-05

6 · The paper itself

Abstract

Psilocybin, a psychedelic drug with reported anxiolytic and antidepressant potential, is rapidly metabolized to its active metabolite psilocin. However, a lack of adequate toxicity studies and tissue distribution studies currently restricts its development and application. This study combined behavioral assays in zebrafish with desorption electrospray ionization mass spectrometry imaging (DESI-MSI) to systematically evaluate the acute neurotoxicity of psilocybin and characterize the in vivo spatial distribution of its active metabolite, psilocin. The novel tank test was used to evaluate zebrafish following a 4 h exposure to psilocybin at three different doses (20, 40, and 80 μM;

Indexed as

HallucinogensPsilocybinSpectrometry, Mass, Electrospray IonizationZebrafishAnimalsBehavior, AnimalBrainTissue DistributionHallucinogenspsilocinPsilocybinDESI-MSIneurotoxicitypsilocinpsilocybinspatial distributionzebrafish

Identifiers

PMID42357539

DOI10.3390/molecules31122143

PMCPMC13304545

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.