Evidence map›Paper›PMID 42357928›Full record

ArticleGlia2026

Alzheimer's Protection by PLCγ2 Compacts Plaques, Redistributes Microglia, and Protects Synapses in App

Ryan J Bevan, Emily Maguire, Eilish Mackinnon, Elisa Salis, Thomas Phillips, Elena Simonazzi, Marieta Vassileva, Nicholas D Allen, Julie Williams, Philip R Taylor

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Glia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ryan J BevanUK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK.ORCID 0000-0002-2557-2887
Emily MaguireUK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK.ORCID 0000-0003-0046-318X
Eilish MackinnonUK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK.ORCID 0009-0004-4524-3740
Elisa SalisUK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK.ORCID 0009-0009-0735-4729
Thomas PhillipsUK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK.ORCID 0000-0002-4709-2550
Elena SimonazziUK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK.ORCID 0000-0003-4166-704X
Marieta VassilevaUK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK.ORCID 0009-0000-5475-7891
Nicholas D AllenSchool of Biosciences, Cardiff University, Cardiff, UK.ORCID 0000-0003-4009-186X
Julie WilliamsUK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK.ORCID 0000-0002-4069-0259
Philip R TaylorUK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK.ORCID 0000-0003-0163-1421

Funding

Moondance FoundationUK Dementia Research Institute DRI-3203
6 · The paper itself

Abstract

The Alzheimer's disease protective P522R PLCG2 coding variant (rs72824905) is downstream of TREM2, but how it confers disease protection is poorly understood. Using a Plcg2-R522 knock-in mouse and Plcg2-P522 control on both wildtype and Alzheimer's disease-like App

Indexed as

Alzheimer DiseaseMicrogliaPhospholipase C gammaPlaque, AmyloidSynapsesAmyloid beta-Protein PrecursorAnimalsMiceMice, TransgenicAmyloid beta-Protein PrecursorPhospholipase C gamma

Identifiers

PMID42357928
PMCPMC13305147

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.