Evidence map›Paper›PMID 42358186›Full record

ReviewNano letters2026

Extracellular Vesicles as Nanoparticle Delivery Vectors in Cancer Therapy.

Maria Sancho-Albero, Ana Martín-Pardillos, Jose L Hueso, Victor Sebastian, Jesus Santamaria

Abstract readReview
In one paragraph

Review in Nano letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maria Sancho-AlberoInstituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, Campus Rio Ebro, Edificio I+D, C/Poeta Mariano Esquillor, s/n, Zaragoza 50018, Spain.ORCID 0000-0001-8762-5457
Ana Martín-PardillosInstituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, Campus Rio Ebro, Edificio I+D, C/Poeta Mariano Esquillor, s/n, Zaragoza 50018, Spain.
Jose L HuesoInstituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, Campus Rio Ebro, Edificio I+D, C/Poeta Mariano Esquillor, s/n, Zaragoza 50018, Spain.ORCID 0000-0002-4546-4111
Victor SebastianInstituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, Campus Rio Ebro, Edificio I+D, C/Poeta Mariano Esquillor, s/n, Zaragoza 50018, Spain.ORCID 0000-0002-6873-5244
Jesus SantamariaInstituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, Campus Rio Ebro, Edificio I+D, C/Poeta Mariano Esquillor, s/n, Zaragoza 50018, Spain.ORCID 0000-0002-8701-9745

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three decades after the approval of the first cancer nanomedicine, low (<1%) tumor delivery remains the central unsolved challenge in nanoparticle (NP)-based therapy. This barrier has prompted a research shift toward biologically derived delivery systems able to reduce immune clearance while preserving tumor-homing capabilities. In particular, extracellular vesicles (EVs) seem obvious candidates on account of their intrinsic biocompatibility, cell-specific tropism, and biological functionality. In this mini-review, we critically analyze EVs as nanoparticle delivery vectors in cancer therapy. We describe current EV engineering approaches, including loading methodologies, surface modification strategies, and the development of artificial or biomimetic EVs, highlighting technical, scalability, and characterization challenges. We also summarize key

Indexed as

Antineoplastic AgentsDrug Delivery SystemsExtracellular VesiclesNanoparticle Drug Delivery SystemNanoparticlesNeoplasmsAnimalsHumansNanomedicineTissue DistributionAntineoplastic AgentsNanoparticle Drug Delivery Systemextracellular vesicle engineeringExtracellular vesicles (EVs)nanoparticle deliverytumor targeting

Identifiers

PMID42358186
PMCPMC13352943

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.