Evidence map›Paper›PMID 42358249›Full record

ArticleFrontiers in microbiology2026

Novel insights into gut microbiota alterations in major depressive disorder with suicidal ideation: a metagenomic analysis.

Lulu He, Yuanyuan Huang, Hehua Li, Baoyuan Zhu, Ziyun Zhang, Jingping Wu, Sumiao Zhou, Qianqian Zhan, Kai Wu, Fengchun Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lulu He *The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.
Yuanyuan Huang *The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.
Hehua LiThe Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.
Baoyuan ZhuSchool of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou, China.
Ziyun ZhangThe Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.
Jingping WuThe Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.
Sumiao ZhouThe Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.
Qianqian ZhanThe Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.
Kai WuThe Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.
Fengchun WuThe Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Suicidal ideation in major depressive disorder (MDD) is common, yet its biological mechanisms and biomarkers remain unclear. The gut microbiota, a key component of the gut-brain axis, has been implicated, but current evidence is limited. Methods: We analyzed fecal samples from 141 participants, including 52 healthy controls (HCs) and 89 first-episode, drug-naïve MDD patients, further classified into suicidal ideation (SI, Results: No significant differences were observed in overall microbial diversity. Conclusion:

Indexed as

Bacteroides cellulosilyticusgut microbiomemajor depressive disordermetagenomesuicidal ideation

Identifiers

PMID42358249
PMCPMC13290911

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.