ArticleCurrent opinion in physiology2026
Myeloid cell renin-angiotensin-aldosterone system in hypertension and inflammation.
Article in Current opinion in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
Abstract
This review explores the intersection of the renin-angiotensin-aldosterone system (RAAS) and myeloid cell biology, with particular focus on how their interaction contributes to hypertension pathogenesis and related inflammatory comorbidities. While the classical RAAS is well-established in systemic blood pressure control and fluid balance, evidence is mounting that immune cells possess an intrinsic RAAS that influences inflammatory processes. We highlight recent findings that myeloid cells not only respond to circulating RAAS factors but also express RAAS components, creating local autocrine/paracrine loops. We also examine emerging links between myeloid RAAS signaling and other conditions such as cardiometabolic disorders, autoimmune diseases, infections, and fibrosis, which suggest broad implications beyond blood pressure regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.