Evidence map›Paper›PMID 42358621›Full record

ArticleCell reports. Physical science2026

Mechanistic insights into how water-network disorder determines the vitrification concentration in cryopreservation solutions.

Euihyun Lee, Nora Gaby-Biegel, Rebecca D Sandlin, Carlos R Baiz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Physical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Euihyun LeeDepartment of Chemistry, University of Texas at Austin, Austin, TX 78712, USA.
Nora Gaby-BiegelCenter for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, and Shriner's Children's, Boston, MA, USA.
Rebecca D SandlinCenter for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, and Shriner's Children's, Boston, MA, USA.
Carlos R BaizDepartment of Chemistry, University of Texas at Austin, Austin, TX 78712, USA.

Funding

Protein structure and dynamics in ultra-heterogeneous environments-RenewalR35GM133359 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Carlos Raul Baiz · 2019 to 2026
$1.8M
NIGMS NIH HHS R35 GM133359
6 · The paper itself

Abstract

Cryopreservation enables long-term storage of biological materials using cryoprotective agents (CPAs) to suppress ice crystal formation and prevent cell damage. However, despite considerable efforts, a molecular-level understanding of how CPAs prevent ice-crystal formation has not yet been established, particularly one that generalizes across different CPAs. In this study, we correlate molecular factors derived from low-temperature molecular dynamics simulations with measured C

Identifiers

PMID42358621
PMCPMC13293526

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.