Evidence map›Paper›PMID 42358645›Full record

ReviewFrontiers in cardiovascular medicine2026

The role of sortilin in cardiovascular calcification: mechanisms and therapeutic potential.

Yaqing Yao, Sijia Li, Shuangshuang Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yaqing YaoDepartment of Cardiology, Wenling Hospital of Wenzhou Medical University (The First People's Hospital of Wenling), Wenling, Zhejiang, China.
Sijia LiPsychology Department, Australian National University, Canberra, ACT, Australia.
Shuangshuang WangDepartment of Cardiology, Wenling Hospital of Wenzhou Medical University (The First People's Hospital of Wenling), Wenling, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular calcification is a common pathological feature driving cardiovascular morbidity and mortality. Although traditionally viewed as a passive degenerative process, current evidence demonstrates that calcification is an actively regulated, cell-driven phenomenon involving osteogenic differentiation, inflammation, and metabolic disturbances. Sortilin (encoded by

Indexed as

aortic valve calcificationrisk factorssortilintherapeutic targetvascular calcification

Identifiers

PMID42358645
PMCPMC13291156

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.