ReviewChemical & biomedical imaging2026
pH-Responsive Materials for Therapy and Precision Biomedical Imaging.
Review in Chemical & biomedical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The acidic tumor microenvironment (TME) presents a key pathological hallmark that can be exploited for targeted therapeutic and diagnostic interventions. This review systematically outlines the design and application of pH-responsive materials in biomedical imaging and therapy, emphasizing their role in achieving spatial and temporal control over drug delivery and imaging contrast. We first detail the fundamental chemical mechanisms underpinning pH responsiveness, including dynamic covalent bonds (e.g., acylhydrazone, imine, orthoester, and borate ester), metal-ligand coordination bonds, and pH-dependent noncovalent interactions. These principles are then translated into a variety of nanocarrier platforms, such as polymeric micelles, liposomes, hydrogels, metal-organic frameworks (MOFs), PROTAC conjugates, and self-assembling peptides, all of which are designed to undergo structural or functional changes in response to acidic conditions. The convergence of these smart materials with advanced imaging modalities has enabled transformative applications, including activatable probes for high-contrast functional imaging, multistimuli responsive theranostics, organelle-precision targeting, and spatiotemporally programmed release systems. These innovations collectively enhance diagnostic accuracy, therapeutic specificity, and the potential for real-time treatment monitoring. However, clinical translation remains challenged by issues related to reproducible synthesis, long-term biocompatibility, and the complex heterogeneity of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.