Evidence map›Paper›PMID 42358941›Full record

ArticleFrontiers in immunology2026

Trisomy 8 clonal expansion during disease progression and azacitidine resistance in VEXAS syndrome: a case report.

Keijiro Sato, Yoshitaka Zaimoku, Yui Kano, Miku Kobayashi, Shintaro Kazama, Takahiro Morikawa, Hiroko Kazumoto, Wataru Ishii, Toshimitsu Ueki, Masahiko Sumi and 4 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Keijiro SatoDepartment of Hematology, Japanese Red Cross Nagano Hospital, Nagano, Japan.
Yoshitaka ZaimokuDepartment of Hematology, Kanazawa University Hospital, Kanazawa, Japan.
Yui KanoDepartment of Clinical Laboratory Science, Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Miku KobayashiDepartment of Clinical Laboratory Science, Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Shintaro KazamaDepartment of Hematology, Japanese Red Cross Nagano Hospital, Nagano, Japan.
Takahiro MorikawaDepartment of Hematology, Japanese Red Cross Nagano Hospital, Nagano, Japan.
Hiroko KazumotoDepartment of Hematology, Japanese Red Cross Nagano Hospital, Nagano, Japan.
Wataru IshiiDepartment of Rheumatology, Japanese Red Cross Nagano Hospital, Nagano, Japan.
Toshimitsu UekiDepartment of Hematology, Japanese Red Cross Nagano Hospital, Nagano, Japan.
Masahiko SumiDepartment of Hematology, Japanese Red Cross Nagano Hospital, Nagano, Japan.
Hikaru KobayashiDepartment of Hematology, Japanese Red Cross Nagano Hospital, Nagano, Japan.
Yasuhito NannyaDivision of Hematopoietic Disease Control, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Seishi OgawaDepartment of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan.
Naoaki IchikawaDepartment of Medical Oncology, Japanese Red Cross Nagano Hospital, Nagano, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome is an adult-onset autoinflammatory disorder driven by clonal hematopoiesis with somatic Case presentation: A 61-year-old man presented with predominant gastrointestinal symptoms, macrocytic anemia, thrombocytopenia, and systemic inflammation. A bone marrow examination revealed cytoplasmic vacuoles in myeloid precursors and trisomy 8. Retrospective genetic testing identified a somatic Conclusion: This case suggests that trisomy 8 may contribute to disease progression and azacitidine resistance in VEXAS syndrome.

Indexed as

AzacitidineDrug ResistanceTrisomyChromosomes, Human, Pair 8Disease ProgressionHumansMaleMiddle AgedMutationMyelodysplastic SyndromesSkin Diseases, GeneticUbiquitin-Activating EnzymesAzacitidineUBA1 protein, humanUbiquitin-Activating Enzymesazacitidine resistancecord blood transplantationmyelodysplastic syndrometrisomy 8VEXAS syndrome

Identifiers

PMID42358941
PMCPMC13290977

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.