Evidence map›Paper›PMID 42359580›Full record

ReviewAdvanced healthcare materials2026

Extracellular Vesicles in Wearable Delivery Systems for Cosmeceutical Applications.

Tiantai Wen, Yifan Gu, Guozhen Liu

Abstract readReview
In one paragraph

Review in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tiantai WenIntegrated Devices and Intelligent Diagnosis (ID2) Laboratory, CUHKSZ-Boyalife Regenerative Medicine Engineering Joint Laboratory, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China.
Yifan GuIntegrated Devices and Intelligent Diagnosis (ID2) Laboratory, CUHKSZ-Boyalife Regenerative Medicine Engineering Joint Laboratory, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China.
Guozhen LiuIntegrated Devices and Intelligent Diagnosis (ID2) Laboratory, CUHKSZ-Boyalife Regenerative Medicine Engineering Joint Laboratory, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China.ORCID https://orcid.org/0000-0002-0556-6404

Funding

1+1+1 CUHK-CUHK(SZ)-GDSTC Joint Collaboration FundCUHKSZ-Boyalife Joint Laboratory FundGuangdong Basic Research Center of Excellence for Aggregate Science FundGuangdong Pearl River Talent Program 2021CX02Y066National Natural Science Foundation of China 22174121National Natural Science Foundation of China 22211530067National Natural Science Foundation of China T2250710180Natural Science Foundation of Guangdong Provincial Basic and Applied Basic Research Fund 2022 GuangdongHybribioShenzhen Bay Open Laboratory Fund 2021University Development Fund UDF01002012
6 · The paper itself

Abstract

Extracellular vesicles (EVs) have attracted increasing interest in cosmeceuticals due to their regenerative, anti-inflammatory, and skin-repairing properties. However, conventional topical and injectable EV delivery approaches are often limited by poor skin penetration, instability, and inconsistent bioavailability. This review summarizes recent advances in wearable-assisted EV delivery systems for cosmetic and dermatological applications, with particular emphasis on transdermal delivery strategies, sustained release, and personalized skin monitoring. Wearable platforms, including microneedle patches, hydrogels, iontophoretic devices, and stimuli-responsive systems, may improve EV retention, transdermal transport, and localized delivery compared with conventional topical formulations. Different EV sources and wearable formats are discussed together with their advantages, formulation considerations, and translational limitations. Despite these opportunities, challenges related to EV stability, scalable production, regulatory classification, and long-term safety remain important barriers to clinical and commercial translation. Continued advances in biomaterials, wearable electronics, and formulation strategies may further support the development of EV-enabled personalized skincare systems.

Indexed as

CosmeceuticalsDrug Delivery SystemsExtracellular VesiclesWearable Electronic DevicesAdministration, CutaneousAnimalsHumansMicroneedle Drug DeliverySkinCosmeceuticalsclinical efficacy of EVscosmeceuticalsextracellular vesiclestopical EVs deliverytransdermal EVs applicationwearable devices

Identifiers

PMID42359580
PMCPMC13410814

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.