Evidence map›Paper›PMID 42359587›Full record

ArticleAdvanced healthcare materials2026

Engineering Urchin-Shaped Copper Nanospheres for Synergistic Apoptosis and Cuproptosis via Oxidative Stress Amplification in Cancer Therapy.

Si Wang, Jiarong Liang, Zhonghui Ma, Xiangkun Li, Fei Kuang, Zhiyi Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Si WangSpin-X Institute, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, China.
Jiarong LiangSpin-X Institute, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, China.
Zhonghui MaSpin-X Institute, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, China.ORCID https://orcid.org/0009-0006-9781-0684
Xiangkun LiSpin-X Institute, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, China.
Fei KuangSpin-X Institute, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, China.
Zhiyi WangSchool of Materials, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, China.

Funding

National Key Research and Development Program of China 2023YFB3507003National Natural Science Foundation of China 22377026National Natural Science Foundation of China 52001008Shenzhen Science and Technology Program JCYJ20250604175505007The Medicine-Engineering Convergence Seed Fund (2025) at Sun Yat-sen University
6 · The paper itself

Abstract

The clinical application of conventional chemotherapy is significantly limited by severe toxic side effects, creating an urgent demand for the development of high-performance nanomedicines that can enhance therapeutic efficacy while minimizing adverse reactions. Herein, we develop artemisinin-loaded urchin-shaped copper nanospheres (ART@HCuMSN) for synergistic induction of apoptosis and cuproptosis via oxidative stress amplification in cancer therapy. ART@HCuMSN exhibit tumor microenvironment-activated catalytic activity, wherein released Cu

Indexed as

ApoptosisCopperCuproptosisNanospheresNeoplasmsOxidative StressAnimalsCell Line, TumorHumansMiceCopperapoptosiscuproptosisIn situ catalytic reactionsynergistic therapy

Identifiers

PMID42359587
PMCPMC13410442

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.