ArticleMolecular medicine reports2026
Regulatory function of ten‑eleven translocation‑2 in transcriptional mechanisms of demethylated myeloma cells.
Article in Molecular medicine reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Multiple myeloma (MM) is a malignant plasma cell disorder characterized by clonal expansion of plasma cells in bone marrow. Genetic aberrations in MM are well‑established, while epigenetic alterations, particularly DNA methylation, are increasingly recognized as key regulators of gene expression. The modified bases 5‑methylcytosine (5‑mC) and 5‑hydroxymethylcytosine (5‑hmC) occur in gene promoters and regulatory regions. While the presence of 5‑mC in the promoter is associated with transcriptional silencing, 5‑hmC, generated by oxidation of 5‑mC through ten‑eleven translocation (TET), is associated with gene activation. The present study investigated promoter‑specific 5‑hmC and 5‑mC levels in
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