Evidence map›Paper›PMID 42359648›Full record

ArticleMolecular medicine reports2026

Sulforaphane attenuates cisplatin‑induced acute kidney injury by inhibiting oxidative stress, inflammation and apoptosis via regulation of NRF2.

Zeyu Wu, Mengting Lu, Lei Xu, Ming Luo, Limei Shan, Hongxia Xing, Wenwen Li, Junling Qian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zeyu Wu *Department of Cardiothoracic Surgery, Nanjing Jiangning Hospital, Nanjing Medical University, Nanjing, Jiangsu 211100, P.R. China.
Mengting Lu *Department of Nephrology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu 211112, P.R. China.
Lei XuDepartment of Cardiothoracic Surgery, Nanjing Jiangning Hospital, Nanjing Medical University, Nanjing, Jiangsu 211100, P.R. China.
Ming LuoDepartment of Cardiothoracic Surgery, Nanjing Jiangning Hospital, Nanjing Medical University, Nanjing, Jiangsu 211100, P.R. China.
Limei ShanDepartment of Cardiothoracic Surgery, Nanjing Jiangning Hospital, Nanjing Medical University, Nanjing, Jiangsu 211100, P.R. China.
Hongxia XingDepartment of Nephrology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu 211112, P.R. China.
Wenwen LiDepartment of Nephrology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu 211112, P.R. China.
Junling QianDepartment of Cardiothoracic Surgery, Nanjing Jiangning Hospital, Nanjing Medical University, Nanjing, Jiangsu 211100, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cisplatin‑induced acute kidney injury (CI‑AKI) is one of the most common comorbidities in patients undergoing chemotherapy, notably limiting the clinical use of cisplatin. However, the pathogenesis of CI‑AKI remains to be fully elucidated. Sulforaphane (SFN), a NRF2 agonist, exhibits anti‑inflammatory, antioxidant and anti‑apoptotic effects, thus SFN exerts protective effects in kidney injury diseases. However, the possible role and underlying mechanisms of SFN in CI‑AKI remain ambiguous. An

Indexed as

Acute Kidney InjuryApoptosisCisplatinInflammationIsothiocyanatesNF-E2-Related Factor 2Oxidative StressAnimalsDisease Models, AnimalKidneyMaleMiceMice, Inbred C57BLSulfoxidesCisplatinIsothiocyanatesNF-E2-Related Factor 2sulforaphaneSulfoxidesapoptosiscisplatin‑induced acute kidney injuryinflammationnuclear factor erythroid‑2‑related factor 2oxidative stresssulforaphane

Identifiers

PMID42359648
PMCPMC13320590

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.