Evidence map›Paper›PMID 42359680›Full record

ArticleInternational journal of molecular medicine2026

Recombinant myonectin ameliorates sepsis‑induced cardiomyopathy by alleviating mitochondrial dysfunction via the AdipoR1/AMPK pathway.

Peipei Li, Rui Chen, Hanmo Zhang, Lihong Li, Huiling Luo, Beibei Du, Ping Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Peipei LiDepartment of Cardiology, China‑Japan Union Hospital of Jilin University, Jilin Provincial Cardiovascular Research Institute, Changchun, Jilin 130031, P.R. China.
Rui ChenCardiovascular Hospital, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Hanmo ZhangSchool of Medicine, Nankai University, Tianjin 300350, P.R. China.
Lihong LiDepartment of Pharmacy, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130031, P.R. China.
Huiling LuoDepartment of Cardiology, China‑Japan Union Hospital of Jilin University, Jilin Provincial Cardiovascular Research Institute, Changchun, Jilin 130031, P.R. China.
Beibei DuDepartment of Cardiology, China‑Japan Union Hospital of Jilin University, Jilin Provincial Cardiovascular Research Institute, Changchun, Jilin 130031, P.R. China.
Ping YangDepartment of Cardiology, China‑Japan Union Hospital of Jilin University, Jilin Provincial Cardiovascular Research Institute, Changchun, Jilin 130031, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis‑induced cardiomyopathy (SIC) is a common complication of sepsis and is associated with a high mortality rate; however, effective therapies remain lacking. Mitochondrial dysfunction is a key pathogenic mechanism. Myonectin, also known as C1q tumor necrosis factor‑related protein 15, is a novel member of the C1q/TNF‑related protein family. It has been demonstrated to exert cardioprotective effects by suppressing inflammatory response, inhibiting apoptosis and attenuating cardiac fibrosis. Despite these known functions, whether myonectin protects against SIC remains unclear. The present study aimed to investigate the protective potential of recombinant myonectin (rMyonectin) against SIC. Lipopolysaccharide (LPS)‑induced and cecal ligation and puncture‑induced SIC models were established in C57BL/6J mice, and LPS‑stimulated neonatal mouse cardiomyocytes (NMCMs) were used for

Indexed as

AMP-Activated Protein KinasesCardiomyopathiesMitochondriaMitochondria, HeartReceptors, AdiponectinRecombinant ProteinsSepsisSignal TransductionAnimalsApoptosisMaleMembrane Potential, MitochondrialMiceMice, Inbred C57BLMyocytes, Cardiacadiponectin receptor 1, mouseAMP-Activated Protein KinasesReceptors, AdiponectinRecombinant Proteinsapoptosismitochondrial biogenesismitochondrial dynamicsmyonectinsepsis‑induced cardiomyopathy

Identifiers

PMID42359680
PMCPMC13314204

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.