Evidence map›Paper›PMID 42359700›Full record

ArticleCancer science2026

A Three-Dimensional Culture-Drug Sensitivity Test Predicts MDM2 Inhibitor-Sensitivity in SMARCB1/INI1-Deficient Tumors.

Hiroaki Goto, Chiyoko Nishime, Takashi Ohtsu, Mieko Ito, Maiko Sagisaka, Takuya Naruto, Norihiko Kitagawa, Mio Tanaka, Masakatsu Yanagimachi, Yukihiko Hiroshima and 3 more

Abstract read
In one paragraph

Article in Cancer science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hiroaki GotoDivision of Hematology/Oncology, Kanagawa Children's Medical Center, Yokohama, Japan.ORCID https://orcid.org/0000-0001-6737-1509
Chiyoko NishimeCentral Institute for Experimental Medicine and Life Science, Kawasaki, Japan.
Takashi OhtsuDivision of Advanced Cancer Therapeutics, Kanagawa Cancer Center Research Institute, Yokohama, Japan.
Mieko ItoClinical Research Institute, Kanagawa Children's Medical Center, Yokohama, Japan.
Maiko SagisakaClinical Research Institute, Kanagawa Children's Medical Center, Yokohama, Japan.
Takuya NarutoClinical Research Institute, Kanagawa Children's Medical Center, Yokohama, Japan.
Norihiko KitagawaDepartment of Surgery, Kanagawa Children's Medical Center, Yokohama, Japan.
Mio TanakaDepartment of Pathology, Kanagawa Children's Medical Center, Yokohama, Japan.
Masakatsu YanagimachiDivision of Hematology/Oncology, Kanagawa Children's Medical Center, Yokohama, Japan.
Yukihiko HiroshimaDivision of Advanced Cancer Therapeutics, Kanagawa Cancer Center Research Institute, Yokohama, Japan.ORCID https://orcid.org/0009-0005-7384-3513
Junko TakitaDepartment of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yasuhide HayashiGunma Children's Medical Center, Shibukawa, Japan.
Yohei MiyagiMolecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan.ORCID https://orcid.org/0000-0002-0056-7010

Funding

JSPS KAKENHI 22K07903
6 · The paper itself

Abstract

Loss of SMARCB1/INI1 expression is a common feature of various types of tumors including malignant rhabdoid tumor, an aggressive cancer of children. Because SMARCB1/INI1 deficiency leads to genome-wide transcriptional dysregulation, identifying a specific therapeutic target that acts on a wide range of SMARCB1/INI1-deficient tumors has been challenging. This study aimed to establish if the personalized selection of effective drugs against SMARCB1/INI-deficient tumors is possible by in vitro drug sensitivity profiling. The in vitro drug sensitivity profiles of tumors from SMARCB1/INI1-deficient tumor cell line-derived mouse xenograft (CDX) models were evaluated by a short-term collagen gel-embedded three-dimensional culture-drug sensitivity test (3D-DST). With the 3D-DST, molecular targeting drugs, including inhibitors of aurora B kinase, mammalian target of rapamycin, mitogen-activated protein kinase, WNT/β-catenin, or mouse double minute 2 homolog (MDM2), were selected as therapeutic drug candidates in SMARCB1/INI1-deficient tumors. A CDX tumor, which was resistant to MDM2 inhibitors in the 3D-DST, expressed lower TP53 compared to an MDM2 inhibitor-sensitive tumor. In cultured cell lines, exposure to MI-773, a MDM2 inhibitor, disturbed the expression of a significant number of genes and induced p21 protein expression in MDM2 inhibitor-sensitive cells. However, such changes were not observed in resistant cells. These results suggest that 3D-DST can predict biologically relevant drug sensitivity profiles in SMARCB1/INI1-deficient tumors.

Indexed as

INI1in vitro drug sensitivity testMDM2 inhibitorSMARCB1three‐dimensional culture

Identifiers

PMID42359700
PMCPMC13394486

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.