ReviewInternational journal of oncology2026
Understanding the epigenetic regulation of lactylation and aberrant lactate metabolism in cancer: From mechanisms to therapeutic strategies (Review).
Review in International journal of oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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11 authors.
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Abstract
Tumor metabolic reprogramming is a hallmark of cancer, supporting adaptation to hostile microenvironments and sustained malignancy. Among these changes, abnormal lactate metabolism is central to tumor progression, immune evasion and therapy resistance. Lactate, once considered a mere glycolytic byproduct, also acts as a signaling molecule influencing cancer behavior. Epigenetic mechanisms, including DNA/RNA methylation, histone modifications and non‑coding RNAs, serve key roles in regulating lactate metabolism. Notably, lactylation, a novel post‑translational modification, links lactate metabolism with epigenetic control. The present review outlines the molecular basis of lactate dysregulation, its epigenetic control and its biological impact on cancer, and highlights emerging therapeutic strategies targeting lactate metabolism.
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