Evidence map›Paper›PMID 42360015›Full record

ArticleJournal of diabetes research2026

Mediation by Lipid-Glucose Metabolic Indices in the Association Between Overweight and T2DM Among Shanghai Community-Dwelling Older Adults.

Jia Bo, Hongfei Mo, Fei Wu, Jiayun Zhu, Qinghua Yan, Fan Wang, Minna Cheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jia BoSchool of Nursing and Health Management, Shanghai University of Medicine & Health Sciences, Shanghai, China, sumhs.edu.cn.ORCID https://orcid.org/0009-0002-0129-9887
Hongfei MoSchool of Public Health, Fudan University, Shanghai, China, fudan.edu.cn.ORCID https://orcid.org/0000-0002-4436-6691
Fei WuDivision of Chronic Non-Communicable Disease and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China, scdc.sh.cn.
Jiayun ZhuSchool of Nursing and Health Management, Shanghai University of Medicine & Health Sciences, Shanghai, China, sumhs.edu.cn.
Qinghua YanDivision of Chronic Non-Communicable Disease and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China, scdc.sh.cn.
Fan WangSchool of Public Health, Fudan University, Shanghai, China, fudan.edu.cn.ORCID https://orcid.org/0000-0002-1869-4552
Minna ChengDivision of Chronic Non-Communicable Disease and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China, scdc.sh.cn.ORCID https://orcid.org/0000-0002-1270-6153

Funding

Noncommunicable Chronic Diseases-National Science and Technology 2024ZD0524200Shanghai University of Medicine and Health Sciences A3-2601-26-311009
6 · The paper itself

Abstract

objectiveThis study is aimed at exploring the mediating roles of the triglyceride-glucose (TyG) index, cholesterol-HDL-glucose (CHG) index, and atherogenic index of plasma (AIP) in the association between overweight and Type 2 diabetes mellitus (T2DM) among older adults in Shanghai, China.

methodsA total of 44,715 participants aged ≥ 60 years from the Shanghai Non-communicable Diseases Management Cohort were included. Overweight was defined as a body mass index (BMI) ≥ 24 kg/m

resultsThe mean age of the participants was 77 ± 6.8 years, 16,835 (37.65%) were diagnosed with T2DM, and 27,880 (62.35%) did not. In covariate-adjusted models, overweight older adults had a 26% higher odds of T2DM than nonoverweight older adults. The TyG, CHG, and AIP indices were all associated with T2DM. In the mediation analysis, the proportions of the total effect mediated by the TyG, CHG, and AIP indices were 22.03%, 32.24%, and 6.47%, respectively.

conclusionThe lipid-glucose metabolic indices examined, particularly CHG and TyG indices, partially mediated the association between overweight and T2DM. These biomarkers may serve as early intervention targets to prevent T2DM among overweight older adults.

Indexed as

Blood GlucoseDiabetes Mellitus, Type 2LipidsOverweightTriglyceridesAgedAged, 80 and overBiomarkersBody Mass IndexChinaCholesterol, HDLFemaleHumansIndependent LivingMaleMiddle AgedBiomarkersBlood GlucoseCholesterol, HDLLipidsTriglycerideslipid-glucose metabolic indicesmediation analysisolder adultsoverweightType 2 diabetes mellitus (T2DM)

Identifiers

PMID42360015
PMCPMC13307189

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.