Evidence map›Paper›PMID 42360113›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

THBS1

Xiangxi Kong, Qize Xue, Xiaoan Wei, Jie Li, Bao Huang, Weishao Chen, Zimin Cai, Tao Yang, Chengjun Yao, Jiayan Jin and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Xiangxi KongDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China.
Qize XueDepartment of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, P. R. China.
Xiaoan WeiDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China.
Jie LiDepartment of Orthopaedic Surgery, The Affiliated LiHuiLi Hospital of Ningbo University, Ningbo, P. R. China.
Bao HuangDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China.
Weishao ChenSchool of Medicine, Hangzhou City University, Hangzhou, P. R. China.
Zimin CaiDepartment of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, P. R. China.
Tao YangDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China.
Chengjun YaoDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China.
Jiayan JinDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China.
Bohan CaiDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China.
Xuyang ZhangDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China.
Junhui LiuDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China.ORCID https://orcid.org/0000-0002-8532-2193
Haihao WuDepartment of Orthopedics Surgery, Ningbo No.2 Hospital, Ningbo, Zhejiang, P. R. China.
Jian ChenDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China.ORCID https://orcid.org/0000-0001-8568-9991
Zhi ShanDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China.ORCID https://orcid.org/0000-0003-1649-9945
Fengdong ZhaoDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China.

Funding

National Natural Science Foundation of China 82572791 82272521 82302732Zhejiang Provincial Natural Science Foundation of China LZ23H060002
6 · The paper itself

Abstract

Modic changes (MCs) in the lumbar vertebral endplates are a common imaging finding in patients with low back pain. Their pathogenesis and progression are closely linked to the local immune microenvironment, underscoring the need to investigate the immunomodulatory mechanisms involved in MCs. Here, we identified the THBS1

Indexed as

cutibacterium acnesmacrophagesmodic changesNLRP3 inflammasomeSDC4THBS1

Identifiers

PMID42360113
PMCPMC13336481

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.