Screening and Identification of Novel Peony Seed Peptides with High Antioxidant and Hypoglycemic Activities: Enzymolysis, In vitro Digestion and Molecular Docking.

Chuang Xu, Yulu Wang, Guoyong Guo, Ye Yue, Bo Zhang, Huazhi Xiao, Zhanzhong Wang

Abstract read

In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Chuang XuSchool of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin, 300072, China.

Yulu WangSchool of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin, 300072, China.

Guoyong GuoSchool of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin, 300072, China.

Ye YueSchool of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin, 300072, China.

Bo ZhangSchool of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, 300401, China.

Huazhi XiaoSchool of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin, 300072, China.

Zhanzhong WangSchool of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, 300401, China. wzz7698@tju.edu.cn.ORCID http://orcid.org/0000-0002-9151-3308

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The potential of peony seed meal protein (PSMP) as a source of bioactive peptides has not been fully explored. Three novel peptides (PADAPF, FDQGNF, AVFPSIVGRPR) with antioxidant and hypoglycemic activities were screened from the gastrointestinal digest (GID) of alcalase-hydrolyzed PSMP via enzymolysis, in vitro digestion, and molecular docking. Among four proteases (alcalase, protamex, papain, trypsin), alcalase hydrolysate (ALH) exhibited the highest digestive stability after in vitro gastrointestinal digestion. ALH-GID retained strong DPPH (1,1-diphenyl-2-picrylhydrazyl)/ABTS (2,2'-azinobis (3-ethyl-benzothiazoline-6-sulphonic acid) diammonium salt) radical scavenging ability (0.44 ± 0.01 mg hydrolysate/mL and 0.67 ± 0.04 mg hydrolysate/mL, respectively), reducing power (0.617) and α-glucosidase inhibitory activity (IC

Indexed as

AntioxidantsHypoglycemic AgentsPaeoniaPeptidesPlant ProteinsSeedsalpha-GlucosidasesBioactive Peptides, DietaryBiphenyl CompoundsDigestionHep G2 CellsHumansMolecular Docking SimulationPeptide HydrolasesPicrates1,1-diphenyl-2-picrylhydrazylalpha-GlucosidasesAntioxidantsBioactive Peptides, DietaryBiphenyl CompoundsHypoglycemic AgentsPeptide HydrolasesPeptidesPicratesPlant ProteinsBioactive peptidesHepG2 cellsOxidative stressPeony seed proteinα-glucosidase inhibitory activity

Identifiers

PMID42360359

DOI10.1016/j.jff.2017.06.024

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.