Evidence map›Paper›PMID 42360595›Full record

ArticleUpdates in surgery2026

Flap reconstruction versus primary perineal closure after abdominoperineal resection: a systematic review and meta-analysis.

Yuzhou Wu, Yu Shen, Zhao Zhang, Tinghan Yang, Ziqiang Wang

Abstract read
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Article in Updates in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Yuzhou Wu *Colorectal Cancer Center, Department of General Surgery, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang Street, Chengdu, Sichuan Province, China.
Yu Shen *Colorectal Cancer Center, Department of General Surgery, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang Street, Chengdu, Sichuan Province, China.
Zhao ZhangThe General Hospital of Western Theater Command PLA, Chengdu, China.
Tinghan YangColorectal Cancer Center, Department of General Surgery, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang Street, Chengdu, Sichuan Province, China. timbermcq@vip.qq.com.
Ziqiang WangColorectal Cancer Center, Department of General Surgery, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang Street, Chengdu, Sichuan Province, China. wangziqiang@scu.edu.cn.ORCID http://orcid.org/0000-0002-2874-1535

Funding

National Natural Science Foundation of China 82103541National Natural Science Foundation of China 82203394National Natural Science Foundation of China 82203474Science and Technology Department of Sichuan Province 2021YFS0025Science and Technology Department of Sichuan Province No. 2022YFS0162the Postdoctoral Fellowship Program of CPSF No. GZB20250525University Scientific Research and Innovation Team Program of Sichuan 2019HXFH031University Scientific Research and Innovation Team Program of Sichuan 22HXFH001University Scientific Research and Innovation Team Program of Sichuan No. 20HXJS003
6 · The paper itself

Abstract

backgroundAbdominoperineal resection (APR), extralevator APR (ELAPE), and pelvic exenteration are indispensable for ultra-low pelvic malignancies but frequently create large perineal defects with substantial wound morbidity. Myocutaneous flap reconstruction (FR) has been proposed to reduce these complications compared to primary closure (PC), but evidence remains inconsistent.

methodsA systematic review and meta-analysis was conducted following PRISMA guidelines (PROSPERO CRD420251250827). Databases were searched, and studies comparing postoperative complications of FR to PC after APR/ELAPE/PE were included. The primary outcome was perineal wound complications. Secondary outcomes included major/minor perineal wound complications, perineal hernia, small-bowel obstruction, unplanned readmission, and length of hospital stay. Pooled odds ratios (ORs) and mean differences (MD) were calculated.

resultsA total of 18 studies (2614 patients) were included. The preoperative radiation rate was higher in the FR group (66.4 vs. 50.2%, p < 0.05). The overall perineal wound complication rates were comparable between PC and FR groups (OR 0.90, 95% CI 0.56-1.47, p = 0.687, I

conclusionMyocutaneous flap reconstruction may reduce the risk of pelvic abscess and major pelvic complications after APR/ELAPE. Further high-quality trials are needed to confirm this finding.

Indexed as

Abdominoperineal resectionmyocutaneous fl ap reconstructionperineal woundcomplicationsprimary perineal closure

Identifiers

PMID42360595

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.