Evidence map›Paper›PMID 42360635›Full record

ArticleEuropean journal of epidemiology2026

The SINTER study: a recall-by-genotype design with multidimensional musculoskeletal phenotyping across internal-medicine outpatient clinics.

Kirsty Huininga, Fjorda Koromani, Siwen Li, Katerina Trajanoska, Kirsten A Berk, Mariëtte R Boon, Layal Chaker, Paul van Daele, Johannes Hofland, Mandy H van Hoek and 15 more

Abstract read
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In one paragraph

Article in European journal of epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Kirsty Huininga *Internal Medicine, Erasmus MC Universitair Medisch Centrum, Dr. Molewaterplein 40, 3015 GD, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands.ORCID http://orcid.org/0009-0007-5094-608X
Fjorda Koromani *Internal Medicine, Erasmus MC Universitair Medisch Centrum, Dr. Molewaterplein 40, 3015 GD, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands.
Siwen LiInternal Medicine, Erasmus MC Universitair Medisch Centrum, Dr. Molewaterplein 40, 3015 GD, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands.
Katerina TrajanoskaInternal Medicine, Erasmus MC Universitair Medisch Centrum, Dr. Molewaterplein 40, 3015 GD, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands.
Kirsten A BerkInternal Medicine, Erasmus MC Universitair Medisch Centrum, Dr. Molewaterplein 40, 3015 GD, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands.
Mariëtte R BoonInternal Medicine, Erasmus MC Universitair Medisch Centrum, Dr. Molewaterplein 40, 3015 GD, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands.
Layal ChakerInternal Medicine, Erasmus MC Universitair Medisch Centrum, Dr. Molewaterplein 40, 3015 GD, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands.
Paul van DaeleInternal Medicine, Erasmus MC Universitair Medisch Centrum, Dr. Molewaterplein 40, 3015 GD, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands.
Johannes HoflandInternal Medicine, Erasmus MC Universitair Medisch Centrum, Dr. Molewaterplein 40, 3015 GD, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands.
Mandy H van HoekInternal Medicine, Erasmus MC Universitair Medisch Centrum, Dr. Molewaterplein 40, 3015 GD, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands.
Marc H HemmelderInternal Medicine, Erasmus MC Universitair Medisch Centrum, Dr. Molewaterplein 40, 3015 GD, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands.
Jeanine E Roeters van LennepInternal Medicine, Erasmus MC Universitair Medisch Centrum, Dr. Molewaterplein 40, 3015 GD, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands.
Marco MediciInternal Medicine, Erasmus MC Universitair Medisch Centrum, Dr. Molewaterplein 40, 3015 GD, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands.
Joanne F OliemanInternal Medicine, Erasmus MC Universitair Medisch Centrum, Dr. Molewaterplein 40, 3015 GD, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands.
Behiye OzcanInternal Medicine, Erasmus MC Universitair Medisch Centrum, Dr. Molewaterplein 40, 3015 GD, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands.
Robin P PeetersInternal Medicine, Erasmus MC Universitair Medisch Centrum, Dr. Molewaterplein 40, 3015 GD, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands.
Francesco Mattace-RasoInternal Medicine, Erasmus MC Universitair Medisch Centrum, Dr. Molewaterplein 40, 3015 GD, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands.
Eskeatnaf MulugetaInternal Medicine, Erasmus MC Universitair Medisch Centrum, Dr. Molewaterplein 40, 3015 GD, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands.
Elisabeth F C van RossumInternal Medicine, Erasmus MC Universitair Medisch Centrum, Dr. Molewaterplein 40, 3015 GD, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands.
Jeroen G J van RooijInternal Medicine, Erasmus MC Universitair Medisch Centrum, Dr. Molewaterplein 40, 3015 GD, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands.
André G UitterlindenInternal Medicine, Erasmus MC Universitair Medisch Centrum, Dr. Molewaterplein 40, 3015 GD, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands.
Wesley J VisserInternal Medicine, Erasmus MC Universitair Medisch Centrum, Dr. Molewaterplein 40, 3015 GD, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands.
Evert F S van VelsenInternal Medicine, Erasmus MC Universitair Medisch Centrum, Dr. Molewaterplein 40, 3015 GD, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands.
M Carola ZillikensInternal Medicine, Erasmus MC Universitair Medisch Centrum, Dr. Molewaterplein 40, 3015 GD, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands.
Fernando RivadeneiraInternal Medicine, Erasmus MC Universitair Medisch Centrum, Dr. Molewaterplein 40, 3015 GD, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands. f.rivadeneira@erasmusmc.nl.

Funding

Horizon 2020 Framework Programme 101021500
6 · The paper itself

Abstract

Bone mineral density (BMD) measured by DXA remains the clinical standard for diagnosing osteoporosis, but fails to capture the heterogeneity of skeletal fragility, particularly in patients with chronic diseases. We hereby describe the design of the EraSmus medIcal CeNTer skEletal fRagility (SINTER) Study, which integrates polygenic scores for BMD (PGS

Indexed as

ComorbidityMultidimensional phenotypingPolygenic scoreRecall by genotypeSkeletal fragility

Identifiers

PMID42360635

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.