Observational studyAmerican journal of respiratory and critical care medicine2026
Occupational exposure to dust and fumes increases risk for future adverse clinical outcomes.
Observational study in American journal of respiratory and critical care medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00608764 (Genetic Epidemiology of Chronic Obstructive Pulmonary Disease), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene)
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Abstract
rationaleOccupational exposures to dust and fumes are associated with increased respiratory symptoms and worse lung function; however, their effect on future clinical outcomes has been incompletely explored.
objectivesTo examine the associations between self-reported occupational exposure to dust and fumes on future respiratory exacerbations, cardiovascular events, and other clinical outcomes in people with a history of smoking.
methodsPeople with a current or former smoking status, aged 45 to 80 years, enrolled in COPDGene were assigned to 4 mutually exclusive occupational exposure groups (no exposure, dust-only exposure, fumes-only exposure, dust-and-fumes exposure) based on questionnaire responses at baseline. Clinical outcomes were assessed prospectively for up to 15 years. Respiratory exacerbations were defined as worsening respiratory symptoms requiring treatment with steroids and/or antibiotics; binary outcomes included atherosclerotic cardiovascular disease (ASCVD), cancer, pneumonia, and blood clots. Multivariable-adjusted models estimated the association between occupational exposure category and each clinical outcome. MEASUREMENTS AND MAIN
resultsAmong 8991 participants (mean ± SD age, 60.1 ± 9.0 years; 51.7% male; 49.3% with a current smoking status), the prevalence of dust-only, fumes-only, and dust-and-fumes exposure was 12.0%, 12.4%, and 34.4%, respectively. Self-reported occupational exposure to both dust and fumes was associated with increased risk of future respiratory exacerbations (adjusted rate ratio, 1.38 [95% CI, 1.26-1.52]) relative to those reporting no exposures. Exposure to both dust and fumes was also associated with an increased risk (adjusted odds ratio [95% CI]) for future ASCVD (1.35 [1.17-1.56]) and pneumonia (1.39 [1.19-1.63]), but was not associated with future cancer or blood clots.
conclusionsSelf-reported occupational exposure to dust and fumes is associated with increased future risk for multiple clinically relevant outcomes among tobacco-exposed individuals. CLINICALTRIALS.GOV: NCT00608764 (COPDGene).
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