A general photoinduced manganese-catalyzed platform for the sequential difunctionalization of [1.1.1]propellane.

Jun Xu, Lin Li, Qing Pang, Manyi Chen, Huamin Wang, Pengfei Zhang

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Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Jun XuCollege of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, Hangzhou Normal University, Hangzhou 311121, China.ORCID 0000-0002-8898-3747

Lin LiCollege of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, Hangzhou Normal University, Hangzhou 311121, China.ORCID 0009-0008-0905-6939

Qing PangCollege of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, Hangzhou Normal University, Hangzhou 311121, China.

Manyi ChenCollege of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, Hangzhou Normal University, Hangzhou 311121, China.

Huamin WangDepartment of Chemistry, Zhejiang University, Hangzhou 310027, China.ORCID 0000-0001-7719-7380

Pengfei ZhangCollege of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, Hangzhou Normal University, Hangzhou 311121, China.ORCID 0009-0007-2772-2934

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bicyclo[1.1.1]pentanes (BCPs) constitute prominent bioisosteric replacements for aromatic frameworks and are frequently incorporated into diverse pharmaceutical compounds. However, current synthetic routes, especially those for the synthesis of sulfonyl BCP derivatives, are hampered by narrow substrate scope and limited functional group tolerance. These constraints underscore the demand for more versatile and operationally practical synthetic strategies. Here, we disclose a general photoinduced manganese-catalyzed platform for the sequential difunctionalization of [1.1.1]propellane, enabling the modular synthesis of multifunctional sulfonyl BCPs. This platform facilitates the construction of diverse sulfonyl-BCP derivatives, including ─Cl, ─Br, ─I, ─CN, ─SCD

Identifiers

PMID42361189

DOI10.1126/sciadv.aeg5293

PMCPMC13308620

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.