Evidence map›Paper›PMID 42362693›Full record

ArticleNature cardiovascular research2026

An integrated cell atlas of 2.4 million cardiac cells across 209 individuals in health and disease.

Yesh Datar, Mark Chaffin, Bridget Simonson, Alex Mandia, Patrick T Ellinor

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cardiovascular research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Yesh DatarCardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-1457-3048
Mark ChaffinCardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1234-5562
Bridget SimonsonCardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0009-0003-5601-0953
Alex MandiaCardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0009-0008-6603-7507
Patrick T EllinorCardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA. ellinor@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-2067-0533

Funding

IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6M
Using Electrocardiogram Genetics to Inform Arrhythmia RiskR01HL157635 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS, MIRSHAHI, TOORAJ · 2022 to 2025
$2.9M
From genetic basis to mechanisms for Heart FailureR01HL177209 · NHLBI · BROAD INSTITUTE, INC. · PI Patrick Thomas Ellinor, Ling Xiao · 2025 to 2026
$1.6M
American Heart Association (American Heart Association, Inc.) 25IPA1456818American Heart Association (American Heart Association, Inc.) 961045EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) MAESTRIA 965286Fondation Leducq 24CVD01NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL157635NHLBI NIH HHS R01 HL177209U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) RO1HL092577, RO1HL157635, R01HL177209
6 · The paper itself

Abstract

Cardiovascular disease remains the leading cause of global mortality. Understanding its complexity requires dissecting the heart's cellular landscape. Here we present HeartMap, a comprehensive single-nucleus RNA sequencing atlas of the adult human heart. This resource integrates data from nine studies, encompassing over 2.4 million nuclei, 209 individuals, eight anatomical regions and seven disease and healthy states. After rigorous data harmonization and method comparison of batch correction methods, we characterized transcriptional diversity across 14 cell types. To demonstrate the utility of HeartMap, we identified robust disease-associated gene signatures in dilated cardiomyopathy by comparing multiple studies. Notably, we identified distinct activated fibroblast populations, enriched for COL22A1 or TNC, that display variable prevalence across cardiomyopathies. HeartMap provides a valuable tool for exploring cardiac disease at the single-cell level, facilitating both fundamental research and potential therapeutic development.

Indexed as

Heart DiseasesMyocardiumMyocytes, CardiacSingle-Cell AnalysisTranscriptomeAdultCardiomyopathy, DilatedFibroblastsGene Expression ProfilingHumansRNA-SeqSingle-Cell Gene Expression Analysis

Identifiers

PMID42362693
PMCPMC13368614

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.