SynthesisEuropean archives of psychiatry and clinical neuroscience2026
Exploring the genetic correlation between inflammatory bowel disease and psychiatric disorders: insights from genome-wide association studies.
Synthesis in European archives of psychiatry and clinical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
Funding
Abstract
backgroundInflammatory bowel disease (IBD) and psychiatric disorders exhibit complex comorbid patterns, with anxiety and depressive disorders being significantly more prevalent in IBD patients compared to the general population. These comorbidities may differ between Crohn's disease (CD) and ulcerative colitis (UC), suggesting heterogeneous but potentially shared genetic mechanisms mediated through the gut-brain axis (GBA).
objectiveTo systematically investigate global and local genetic correlations between IBD and eight psychiatric disorders and to identify shared pathogenic mechanisms underlying these comorbidities.
methodsUsing publicly available large-scale GWAS summary statistics, including a meta-analysis of 486,601 individuals for IBD and large international consortia datasets for eight psychiatric disorders, we conducted global genetic correlation analysis to quantify overall genetic overlap, local genetic correlation analysis to identify region-specific associations, summary data-based Mendelian randomization (SMR) to evaluate putative causal gene-trait relationships, and multi-trait analysis of GWAS (MTAG) to detect pleiotropic variants.
resultsSignificant global genetic correlations were observed between IBD and ADHD (rho = 4.79 × 10
conclusionOur findings provide multi-layered genetic evidence supporting a structured and locus-specific shared genetic architecture between IBD and several psychiatric disorders. The identification of key genes and pathways, particularly NOD2 and immune-synaptic signaling cascades, offers potential molecular targets for understanding and managing comorbid disease within the GBA framework.
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