Evidence map›Paper›PMID 42362883›Full record

ArticleNature neuroscience2026

The mitochondrial unfolded protein response in human microglia disrupts neuronal-glial communication and promotes senescence.

Maria Jose Perez J, Alicia Lam, Christin Weissleder, Federico Bertoli, Hariam Raji, Mariella Bosch, Ivan Nemazanyy, Stefanie Kalb, Mohammed Kehili, Insa Hirschberg and 4 more

Abstract read
In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Maria Jose Perez JMechanisms and Therapy of Genetic Brain Diseases, Institut Imagine, Paris, France. perezm@ie-freiburg.mpg.de.ORCID http://orcid.org/0000-0001-8842-4286
Alicia LamMechanisms and Therapy of Genetic Brain Diseases, Institut Imagine, Paris, France.
Christin WeisslederMechanisms and Therapy of Genetic Brain Diseases, Institut Imagine, Paris, France.ORCID http://orcid.org/0000-0001-8858-9590
Federico BertoliMechanisms and Therapy of Genetic Brain Diseases, Institut Imagine, Paris, France.
Hariam RajiMechanisms and Therapy of Genetic Brain Diseases, Institut Imagine, Paris, France.
Mariella BoschHertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.ORCID http://orcid.org/0009-0004-4890-3679
Ivan NemazanyyPlatform for Metabolic Analyses, Structure Fédérative de Recherche Necker, INSERM US24/CNRS UAR 3633, Paris, France.ORCID http://orcid.org/0000-0001-8080-839X
Stefanie KalbHertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Mohammed KehiliMechanisms and Therapy of Genetic Brain Diseases, Institut Imagine, Paris, France.
Insa HirschbergHertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Dario BrunettiDepartment of Clinical Sciences and Community Health, Excellence Department 2023-2027, University of Milan, Milan, Italy.ORCID http://orcid.org/0000-0002-2740-9370
Indra HeckenbachDepartment of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-7038-4677
Morten Scheibye-KnudsenDepartment of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-6637-1280
Michela DeleidiMechanisms and Therapy of Genetic Brain Diseases, Institut Imagine, Paris, France. michela.deleidi@institutimagine.org.ORCID http://orcid.org/0000-0003-0357-0124

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) #490761034EU Joint Programme - Neurodegenerative Disease Research (Programi i Përbashkët i BE-së për Kërkimet mbi Sëmundjet Neuro-degjeneruese) GBA-PaCTS, 01ED2005BEuropean Molecular Biology Organization (EMBO) ALTF 1013-2019Fondazione Telethon (Telethon Foundation) GSA22I001Michael J. Fox Foundation for Parkinson's Research (Michael J. Fox Foundation) ASAP-000420
6 · The paper itself

Abstract

Mitochondria have evolved a specialized mitochondrial unfolded protein response (UPR

Indexed as

Cell CommunicationCellular SenescenceMicrogliaMitochondriaNeurogliaNeuronsUnfolded Protein ResponseCells, CulturedHumansProteotoxic Stress

Identifiers

PMID42362883
PMCPMC13433254

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.