Evidence map›Paper›PMID 42362890›Full record

SynthesisNature aging2026

Meta-analysis of DNA methylation aging signatures in 17 human tissues.

Macsue Jacques, Kirsten Seale, Sarah Voisin, Anna Lysenko, Robin Grolaux, Bernadette Jones-Freeman, Severine Lamon, Mandhri Abeysooriya, Itamar Levinger, Carlie Bauer and 19 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Embracing non-linearity in human ageing.Nature reviews. Genetics · 2026
    Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Macsue JacquesAustralian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia.
Kirsten SealeTruDiagnostics, Lexington, KY, USA.
Sarah VoisinNovo Nordisk, Copenhagen, Denmark.
Anna LysenkoAustralian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia.
Robin GrolauxAustralian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0001-5129-7308
Bernadette Jones-FreemanAustralian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia.
Severine LamonInstitute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia.
Mandhri AbeysooriyaAustralian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia.
Itamar LevingerInstitute for Health and Sport, Victoria University, Footscray, Victoria, Australia.
Carlie BauerInstitute for Health and Sport, Victoria University, Footscray, Victoria, Australia.
Adam P SharplesInstitute for Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway.
Aino HeikkinenMinerva Foundation Institute for Medical Research, Helsinki, Finland.
Elina SillanpaaFaculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.ORCID http://orcid.org/0000-0001-6375-959X
Miina OllikainenMinerva Foundation Institute for Medical Research, Helsinki, Finland.ORCID http://orcid.org/0000-0003-3661-7400
Cassandra SmithNutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia.
James R BroatchInstitute for Health and Sport, Victoria University, Footscray, Victoria, Australia.ORCID http://orcid.org/0000-0002-0082-3168
Navabeh ZarekookandehInstitute for Health and Sport, Victoria University, Footscray, Victoria, Australia.
Linn GillbergDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Ida BlomDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-1602-3031
Jesse R PoganikDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3098-8550
Mahdi MoqriDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6675-0566
Vadim N GladyshevDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0372-7016
Matthew TaperFaculty of Medicine and Health, The University of Sydney and Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
Cassandra MaleckiFaculty of Medicine and Health, The University of Sydney and Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-2367-9541
Sean LalFaculty of Medicine and Health, The University of Sydney and Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-5841-560X
Nathalie SauratAustralian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia.
Steve HorvathAltos Labs, Cambridge, UK.ORCID http://orcid.org/0000-0002-4110-3589
Andrew TeschendorffShanghai Institute of Nutrition and Health, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0001-7410-6527
Nir EynonAustralian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia. nir.eynon@monash.edu.ORCID http://orcid.org/0000-0003-4613-7865

Funding

Department of Education and Training | Australian Research Council (ARC) DP240102155Department of Education and Training | Australian Research Council (ARC) FT210100278Department of Health | National Health and Medical Research Council (NHMRC) APP1194159Department of Health | National Health and Medical Research Council (NHMRC) MRF1200852National Heart Foundation of Australia (Heart Foundation) 107194National Natural Science Foundation of China (National Science Foundation of China) W2431024Norges Forskningsråd (Research Council of Norway) 314157
6 · The paper itself

Abstract

Epigenetic changes, in particular DNA methylation, accumulate with age across different tissues, but whether these changes follow consistent patterns across different organs remains poorly understood. Here we show, through a meta-analysis of more than 15,000 human methylation profiles spanning 17 tissues, that aging produces both conserved and tissue-specific epigenetic signatures. We identify systemic shifts in methylation levels, increases in methylation variability, and growing molecular disorder across tissues. Network analysis revealed tightly connected gene clusters that are not modified by beneficial interventions, alongside a more modifiable cluster linked to NAD

Indexed as

AgingDNA MethylationEpigenesis, GeneticCadherinsHumansOrgan SpecificityCadherins

Identifiers

PMID42362890
PMCPMC13375584

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.