Evidence map›Paper›PMID 42362969›Full record

ArticleDiabetologia2026

Degree of islet function preservation and continuous glucose monitoring in individuals undergoing total pancreatectomy with islet autotransplantation.

Maarten C Tol, Willemijn E M E de Vos, Ian P J Alwayn, J Sven D Mieog, Jeanin E van Hooft, Akin Inderson, Marieke Niesters, Marieke D Hellinga, Michiel F Nijhoff, Arian R van Erkel and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maarten C TolDepartment of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0001-7064-2947
Willemijn E M E de VosDepartment of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0009-0000-2531-1129
Ian P J AlwaynLUMC Transplant Center, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0003-0603-9849
J Sven D MieogDepartment of Surgery, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-3649-8504
Jeanin E van HooftLUMC Transplant Center, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-4424-0079
Akin IndersonLUMC Transplant Center, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0001-7644-0668
Marieke NiestersDepartment of Anaesthesiology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0009-0002-2822-7509
Marieke D HellingaDepartment of Anaesthesiology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0009-0002-1073-2283
Michiel F NijhoffDepartment of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-5131-2237
Arian R van ErkelDepartment of Radiology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-0298-2015
Marten A EngelseDepartment of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0003-1341-8521
Volkert A L HuurmanLUMC Transplant Center, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-7162-1467
Eelco J P de KoningDepartment of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands. e.j.p.de_koning@lumc.nl.ORCID http://orcid.org/0000-0002-1232-7022

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisIn individuals undergoing total pancreatectomy, an additional islet autotransplantation (total pancreatectomy with islet autotransplantation [TPIAT]) can be performed. We investigated the degree to which islet secretory function is preserved after TPIAT and assessed the relation to glycaemic control using continuous glucose monitoring.

methodsEligibility for TPIAT was assessed by a multidisciplinary team. The cohort consisted of all individuals undergoing TPIAT from 2014 to 2024. To assess islet secretory function, participants were subjected to a 2 h liquid meal stimulation test prior to TPIAT, at 3 months and annually post TPIAT. Glycaemic control was assessed using continuous glucose monitoring and HbA

resultsTwenty-six individuals were included, of whom 88.5% had chronic pancreatitis. At baseline, 57.7% had prediabetes (HbA CONCLUSIONS/

interpretationNearly half of islet secretory function is retained after TPIAT. These results can facilitate shared decisions on the potential benefits of islet autotransplantation after total pancreatectomy, even in individuals with (pre)diabetes and previous pancreatic surgery.

Indexed as

Blood GlucoseIslets of LangerhansIslets of Langerhans TransplantationPancreatectomyAdultContinuous Glucose MonitoringC-PeptideFemaleGlycated HemoglobinHumansMaleMiddle AgedPancreatitis, ChronicTransplantation, AutologousBlood GlucoseC-PeptideGlycated HemoglobinAutologous islet transplantationContinuous glucose monitoringGlycaemic controlIslet functionMixed meal tolerance testTotal pancreatectomyTPIAT

Identifiers

PMID42362969
PMCPMC13424119

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.