Evidence map›Paper›PMID 42363004›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Acute viral encephalitis impacts dense-core amyloid plaque pathology and dysregulates myeloid responses to amyloid plaques.

Dominic Ibarra Javonillo, Susana Furman, Lucas Le, Kellie Fernandez, Jazmyn Mulford, Vidushi Singla, Roshni Jha, Kate Inman Tsourmas, Nellie E Kwang, Kim N Green and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dominic Ibarra JavonilloDepartment of Neurobiology & Behavior, University of California, Irvine, California, USA.
Susana FurmanDepartment of Neurobiology & Behavior, University of California, Irvine, California, USA.
Lucas LeDepartment of Neurobiology & Behavior, University of California, Irvine, California, USA.
Kellie FernandezDeparment of Molecular Biology & Biochemistry, University of California, Irvine, California, USA.
Jazmyn MulfordDepartment of Neurobiology & Behavior, University of California, Irvine, California, USA.
Vidushi SinglaDepartment of Neurobiology & Behavior, University of California, Irvine, California, USA.
Roshni JhaDepartment of Neurobiology & Behavior, University of California, Irvine, California, USA.
Kate Inman TsourmasDepartment of Neurobiology & Behavior, University of California, Irvine, California, USA.
Nellie E KwangDepartment of Neurobiology & Behavior, University of California, Irvine, California, USA.
Kim N GreenDepartment of Neurobiology & Behavior, University of California, Irvine, California, USA.
Thomas E LaneDepartment of Neurobiology & Behavior, University of California, Irvine, California, USA.

Funding

UC Irvine MODEL-ADU54AG054349 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green, FRANK M LAFERLA · 2017 to 2026
$71.9M
Defining mechanisms of disease and repair in a viral model of multiple sclerosisR35NS116835 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Thomas E Lane · 2020 to 2026
$5.0M
Role of Disease-Associated Microglia in Alzheimer's diseaseR01AG081599 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green · 2024 to 2026
$2.3M
Neuroimmunology Training Program at the University of California, IrvineT32NS121727 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green, Thomas E Lane · 2022 to 2026
$854k
Elucidating the role of microglial Beta-hexosaminidase in microglial regulation of perineuronal nets in homeostasis and Alzheimer's diseaseF31NS141599 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI TSOURMAS, KATE INMAN · 2025 to 2025
$47k
Alzheimer's Association 105190National Institutes of Health (NIH-NIA) R01AG081599National Institutes of Health (NIH-NINDS) F31NS141599National Institutes of Health (NIH-NINDS) R35NS116835NIA NIH HHSNIA NIH HHS U54 AG054349NINDS NIH HHSNINDS NIH HHS T32 NS121727
6 · The paper itself

Abstract

introductionRecent epidemiological datasets have associated viral encephalitis exposure (i.e., viral-induced neuroinflammation) with increased risk of Alzheimer's disease (AD) and dementia, highlighting the need to uncover how it may impact AD neuropathology.

methodsAged 5xFAD and wild-type (WT) mice were infected with the John Howard Mueller strain of murine hepatitis virus (JHMV), a neurotropic strain of murine coronavirus to comprehensively determine how coronavirus-induced encephalitis may induce molecular and cellular changes that impact beta-amyloid (Aβ) neuropathology.

resultsJHMV-induced encephalitis at 12 days post-infection resulted in minimal changes to overall Aβ protein, despite increased CD4

conclusionsJHMV encephalitis induces dysregulated gene expression and myeloid cell responses to Aβ plaque burden in 5xFAD mouse brains.

Indexed as

Alzheimer DiseaseEncephalitis, ViralMyeloid CellsPlaque, AmyloidAmyloid beta-PeptidesAnimalsBrainDisease Models, AnimalMacrophagesMiceMice, TransgenicMurine hepatitis virusAmyloid beta-Peptides5xFADAlzheimer's diseaseamyloid‐beta neuropathologycoronavirus infectionmyeloid cellsspatial transcriptomic imagingviral encephalitis

Identifiers

PMID42363004
PMCPMC13309288

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.