Evidence map›Paper›PMID 42363277›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Altered brain glucose metabolism and connectivity in young adults with obstructive sleep apnea.

Silvia P Caminiti, Mariana Fernandes, Claudio Zaccone, Rachele Malito, Agostino Chiaravalloti, Natalia Manfredi, Riccardo Camedda, Francesca Di Giuliano, Marcello D'Amelio, Nicola B Mercuri and 2 more

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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Silvia P CaminitiDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Mariana FernandesDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Claudio ZacconeDepartment of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.
Rachele MalitoNuclear Medicine Unit, IRCCS San Raffaele Hospital, Milan, Italy.
Agostino ChiaravallotiDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
Natalia ManfrediDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Riccardo CameddaDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
Francesca Di GiulianoDepartment of Biomedicine and Prevention, Neuroradiology Unit, University of Rome Tor Vergata, Rome, Italy.
Marcello D'AmelioDepartment of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.
Nicola B MercuriDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Daniela PeraniVita Salute San-Raffaele University, Milan, Italy.
Claudio LiguoriDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.ORCID https://orcid.org/0000-0003-2845-1332

Funding

Ministero dell'Università e della RicercaMinistry of University and Research (MUR)National Recovery and Resilience Plan (NRRP)NEXTGENERATIONEU
6 · The paper itself

Abstract

introductionObstructive sleep apnea syndrome (OSAS) is a recognized risk factor for neurodegenerative disorders. However, a causal link between OSAS and brain damage has yet to be established.

methodsThirty cognitively normal patients with moderate-to-severe OSAS, free from systemic or neurological comorbidities, were enrolled and underwent

resultsGroup-level analyses showed fronto-parietal glucose hypometabolism and cerebellar glucose hypermetabolism in patients with OSAS compared to controls. Cerebellar glucose hypermetabolism was associated with reduced rapid eye movement sleep latency and duration. Seed-based connectivity analysis revealed alterations in attentional and limbic networks. DISCUSSION: Moderate-to-severe OSAS may represent a cause of brain dysfunction, highlighting the importance of its early diagnosis and appropriate treatment to prevent worsening brain damage and possible future neurodegenerative processes. HIGHLIGHTS: Moderate-to-severe obstructive sleep apnea syndrome (OSAS) is associated with altered brain glucose metabolism. Cerebellar glucose hypermetabolism is associated with rapid eye movement sleep impairment. Attentional and limbic networks connectivity is disrupted in moderate-to-severe OSAS. Early recognition of patients with moderate-to-severe OSAS has the potential to overcome the risk of worsening brain damage that may lead to neurodegeneration.

Indexed as

BrainGlucoseSleep Apnea, ObstructiveAdultBrain MappingFemaleFluorodeoxyglucose F18HumansMagnetic Resonance ImagingMaleNeural PathwaysPolysomnographyPositron-Emission TomographyYoung AdultFluorodeoxyglucose F18Glucose18F fluorodeoxyglucose positron emission tomographyattentional networkcerebellumcognitionfrontal lobelimbic networkparietal lobepolysomnographyrapid eye movement sleep

Identifiers

PMID42363277
PMCPMC13309292

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.