ArticleMicrocirculation (New York, N.Y. : 1994)2026
Evaluation of Red Blood Cell Biomechanics in the Setting of Cancer-Associated Anemia and Chemotherapy.
Article in Microcirculation (New York, N.Y. : 1994), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRed blood cells (RBCs) possess distinct biomechanical properties that enable their survival and efficient oxygen delivery. Cancer-associated anemia, frequently compounded by chemotherapy, is a major clinical challenge, yet little is known about how RBC biomechanics contribute to its pathophysiology. This study evaluates the biomechanical properties of RBCs in patients with cancer compared to controls and within patients before and after chemotherapy.
methodsBiomechanical properties of RBCs were assessed in 110 women with breast, ovarian, or endometrial cancer, measured before and after chemotherapy, and compared findings with 35 healthy female controls. Thirteen biomechanical parameters were assessed using the MIZAR automated rheometer.
resultsRelative to controls, pre-chemotherapy cancer patients exhibited significantly higher RBC aggregation and elasticity. Within the cancer cohort, anemic patients demonstrated more deformable and elastic RBCs, with increased aggregation compared to non-anemic patients. Following chemotherapy, patients displayed reduced RBC deformability but further increased elasticity, consistent with chemotherapy-induced alterations to membrane structure and function; these effects were most pronounced in anemic patients.
conclusionWe report novel rheological observations indicating that both cancer and chemotherapy are associated with alterations in RBC biomechanics, and that anemia further amplifies these changes. Importantly, cancer-associated anemia appears to involve impaired RBC quality. Recognition of biomechanical dysfunction may provide new insights into the mechanisms of cancer-related anemia and support the development of more comprehensive diagnostic and management strategies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.