Evidence map›Paper›PMID 42363711›Full record

ReviewBioMed research international2026

Traditional Chinese Medicine Bone-Setting Techniques Research Progress for the Treatment of Knee Osteoarthritis.

Qiao Fan, Ming-Yu Zhao, Xiang-Dong Zhang, Tian-Yun Chu, Zhao-Xi Kou, Qi Zhao, Nan Wang, Xiao-Ying Liu, Jia-Hao Zhang, Qiu-Sheng Wang

Abstract readReview
In one paragraph

Review in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qiao FanHenan Luoyang Orthopedic Hospital (Henan Provincial Orthopedic Hospital), Zhengzhou, Henan Province, China.ORCID https://orcid.org/0009-0006-2434-335X
Ming-Yu ZhaoHenan Luoyang Orthopedic Hospital (Henan Provincial Orthopedic Hospital), Zhengzhou, Henan Province, China.ORCID https://orcid.org/0009-0002-5849-3859
Xiang-Dong ZhangHenan Luoyang Orthopedic Hospital (Henan Provincial Orthopedic Hospital), Zhengzhou, Henan Province, China.
Tian-Yun ChuHenan Luoyang Orthopedic Hospital (Henan Provincial Orthopedic Hospital), Zhengzhou, Henan Province, China.
Zhao-Xi KouHenan Luoyang Orthopedic Hospital (Henan Provincial Orthopedic Hospital), Zhengzhou, Henan Province, China.
Qi ZhaoHenan Luoyang Orthopedic Hospital (Henan Provincial Orthopedic Hospital), Zhengzhou, Henan Province, China.
Nan WangHenan Luoyang Orthopedic Hospital (Henan Provincial Orthopedic Hospital), Zhengzhou, Henan Province, China.
Xiao-Ying LiuHenan Luoyang Orthopedic Hospital (Henan Provincial Orthopedic Hospital), Zhengzhou, Henan Province, China.
Jia-Hao ZhangHenan Luoyang Orthopedic Hospital (Henan Provincial Orthopedic Hospital), Zhengzhou, Henan Province, China.
Qiu-Sheng WangHenan Luoyang Orthopedic Hospital (Henan Provincial Orthopedic Hospital), Zhengzhou, Henan Province, China.

Funding

China Academy of Chinese Medical Sciences YZ-1883Clinical effect of Pingle tendon stagnation bone malocclusion manipulation combined with Jinju analgesic gel in the treatment of knee osteoarthritis of kidney deficiency and blood stasis type in the early stage 2023GBJC03Henan Medical Science and Technology Research Program LHGJ20240452Henan Province Chinese Medicine Top Talent Cultivation Project 2019ZYBJ23Scientific Research Project of Traditional Chinese Medicine in Henan Province 2023ZY1021
6 · The paper itself

Abstract

This paper systematically reviews the biological mechanisms and clinical applications of traditional Chinese medicine (TCM) manual therapy in the treatment of knee osteoarthritis (KOA), explores the scientific basis for its multipathway intervention in improving joint function, and analyzes the current research limitations. KOA is a degenerative joint disease characterized by articular cartilage degeneration, synovitis, and osteophyte formation. Its pathogenesis is closely related to mechanical stress imbalance, abnormal elevation of proinflammatory factors (e.g., IL-1β and TNF-α), and chondrocyte metabolic dysfunction. TCM manual therapy of KOA is to regulate the metabolism of articular cartilage and the production of inflammatory factors through the release of local soft tissue of the knee joint and supplemented by joint motion manipulation. Clinically, KOA should be treated from the perspective of syndrome differentiation, combined with modern anatomy and biomechanics, and pay attention to the circulation of the channel tendons and restore the relative stability of the human structure. In addition, manipulation combined with relevant Chinese medicine therapies such as fumigation, acupoint injection, acupuncture, and so on. can effectively relieve KOA in the elderly. However, there are still some problems in the treatment of KOA by TCM manipulation: for example, the pathogenesis of KOA is not clear, and the mechanism of action of TCM manipulation in the treatment of KOA is still under study. Whether it is the use of holistic, local, or comprehensive therapy, it is still necessary to further clarify its principle of action and better guide clinical practice.

Indexed as

Medicine, Chinese TraditionalOsteoarthritis, KneeCartilage, ArticularHumansKnee Jointknee osteoarthritissummarizetraditional Chinese medicine bone-setting techniques

Identifiers

PMID42363711
PMCPMC13309803

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.